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Polygonum
About: Polygonum is a research topic. Over the lifetime, 1230 publications have been published within this topic receiving 12765 citations.
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TL;DR: Differences between the chemical compositions in the leaves, stems and roots of P. multiflorum Thunb.
Abstract: The differential constituents in leaves, stems and roots of Polygonum multiflorum Thunb. were analyzed by ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC/ESI-Q-TOF-MS) and by multivariate statistical analysis. The established extraction and analysis method showed relative standard deviations (RSDs) for intra-day precision of less than 3.40%, for repeatability of less than 4.06% and for stability of less than 5.10%. Principal component analysis and orthogonal projections to latent structures discriminant analysis of the UPLC/ESI-Q-TOF-MS data showed good ability to classify the leaves, stems and roots of P. multiflorum Thunb. The differential constituents, such as stilbenes, polygoacetophenoside, flavonoids and anthraquinones, accounting for variations between the leaves, stems and roots, were filtered through the variable importance in projection values and were further identified by elemental composition analysis, mass fragmentation data and retention times of available standards. Differences between the chemical compositions in the leaves, stems and roots of P. multiflorum Thunb. were closely related to their various therapeutic effects. This UPLC/ESI-Q-TOF-MS-based analytical strategy could be further utilized to evaluate the overall quality of traditional Chinese medicines and their differences of chemical constituents in different parts of the plant and/or in the plants of different geographical locations.
7 citations
TL;DR: A new hydroxyjasmonic acid derivative, named β-D-glucopyranosyl-12-hydroxy-12-(2″-hydroxyl-2″)-carboxyethyl)jasmonics acid (1), together with 13 known compounds, were isolated from the n-butanol fraction of the ethanol extract of Polygonum capitatum as mentioned in this paper.
Abstract: A new hydroxyjasmonic acid derivative, named β-D-glucopyranosyl-12-hydroxy-12-(2″-hydroxy-2″-carboxyethyl)jasmonic acid (1), together with 13 known compounds, were isolated from the n-butanol fraction of the ethanol extract of Polygonum capitatum. Their structures were determined on the basis of spectral analysis. Compounds 2, 8–10, and 12–14 were obtained from P. capitatum for the first time.
7 citations
01 Jan 2015
TL;DR: Wang et al. as mentioned in this paper detected changes in rat serum and liver tissue metabolites through gas chromatography-mass spectrometry (GC-MS) and other diversified techniques were used to analyze the differences among their metabolites.
Abstract: * Equal contribu- tors. Received April 1, 2015; Accepted June 2, 2015; Epub July 15, 2015; Published July 30, 2015 Abstract: Polygonum multiflorum, a traditional Chinese medicinal herb, is widely used in liver and liver nourishing. Recent years, drug regulatory departments reported that Polygonum multiflorum caused serious adverse reaction in clinic, especially liver injury. In this study, we detected the changes in rat serum and liver tissue metabolites through gas chromatography-mass spectrometry (GC-MS). Mass spectrometry, partial least squares-discriminate analysis (PLS-DA) and other diversified techniques were used to analyze the differences among their metabolites. Compared to the control group, the serum concentrations of L-threonine and serine in water extraction groups increased. The serum concentrations of 9,12-octadecadienoic acid, hexadecanoic acid, oleic acid, D-glucose and octadecanoic acid in alcohol extraction groups increased, while lactic acid decreased to a great extent. For liver tis- sue, compared to the control group, the concentrations of myo-inositol, oleic acid and cholesterol in water extraction groups increased, while those of hexadecanoic acid, octadecanoic acid, ribitol and butanedioic acid decreased to a great extent. The concentrations of myo-inositol, phosphoric acid, uridine, oleic acid, cholesterol and butanoic acid in alcohol extraction groups increased to a great extent, while those of hexadecanoic acid, octadecanoic acid, ribitol and butanedioic acid decreased. The results indicate that Polygonum multiflorum induces the metabolic disorders of energy metabolism, amino acid and lipid metabolism. What's more, liver injury of alcohol extraction group was more serious than group of water extraction.
7 citations
Journal Article•
7 citations