Polygonum

About: Polygonum is a research topic. Over the lifetime, 1230 publications have been published within this topic receiving 12765 citations.

Herb-Drug Interaction: Application of a UPLC-MS/MS Method to Determine the Effect of Polygonum capitatum Extract on the Tissue Distribution and Excretion of Levofloxacin in Rats

Abstract: Polygonum capitatum has unique curative effects on the urinary system In fact, many Polygonum capitatum-based preparations are currently used in the clinic In China, the combination of levofloxacin (LVFX) with a Chinese herbal preparation derived from Polygonum capitatum has been used for the clinical treatment of urinary system diseases, which can improve the curative effects and reduce the side effects of LVFX However, the herb-drug interaction (HDI) between these drugs has not been reported and the effect of Polygonum capitatum on the in vivo process of LVFX is unclear In this article, a sensitive ultraperformance liquid chromatography-tandem mass spectroscopy (UPLC-MS/MS) method was developed to evaluate the effects of the combined application of LVFX and the Polygonum capitatum extract on tissue distribution and excretion Thereafter, the method was validated for selectivity, accuracy, precision, linearity, lower limit of quantification (LLOQ), dilution integrity, recovery, and matrix effect Based on tissue distribution, LVFX could diffuse into all of the tested tissues, with significant differences in the content of each tissue between the coadministration group and single administration group At 48 h after the combination was orally administered, the urinary cumulative excretion of LVFX decreased from 2069% to 1184% while its fecal cumulative excretion decreased from 2608% to 1328% Our results suggest that a drug interaction exists between the two drugs in the process of distribution and excretion This study provides important experimental evidence for further studies on the clinical efficacy and mechanism of the Polygonum capitatum extract and LVFX

On absorption and accumulation of six heavy metal elements of weeds in Jinhua suburb-I Survey on content of six heavy metal elements in weeds and soil

Abstract: The contents of six heavy metal elements including Mn,Zn,Cr,Cu,Pb and Cd in 51 weed samples and 33 sites collected from Jinhua suburb were determined and numerically analyzed. The results are as follows:(1)The organs followed an order as rootsleavesstemsinflorescence and fruit based on their average concentrations of six elements; The elements ranked as ZnMnPbCuCrCd according to their concentrations in weeds,the accumulation coefficients ranked as CdPbZnMnCuCr in weeds;(2)Alternanthera philoxeroides, Clinopodium confines, Veronica undulata, Ranunculus japonicus, Polygonum hydropiper and Onanthe javanica have higher endurance to the contaminations by heavy metal elements. In Alternanthera philoxeroides, the concentrations of Zn are as high as 1699.28mg/kg, 1108.77mg/kg, 753.08mg/kg in root, stem and leaves respectively,that of Mn was 1268.48mg/kg high in roots. In Polygonum hydropiper,the concentration of Mn is as high as 1616.71mg/kg;(3)Not only the concentrations, but also the accumulation coefficients were higher in the weeds growing in contaminated environments.