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Polyvinyl alcohol

About: Polyvinyl alcohol is a(n) research topic. Over the lifetime, 19940 publication(s) have been published within this topic receiving 188284 citation(s). The topic is also known as: PVOH & PVAl.

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Papers
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Journal ArticleDOI: 10.1016/J.POLYMER.2004.01.024
S. A. Theron1, Eyal Zussman1, Eyal Zussman2, Alexander L. Yarin1  +1 moreInstitutions (3)
01 Mar 2004-Polymer
Abstract: In the electrospinning process, polymer nanofibers with submicron-scale diameters are formed when a droplet of a viscoelastic polymer solution is subjected to a high voltage electrostatic field. We report the experimental work on the electrospinning process in which the influence of different process parameters on the electric current and volume and surface charge density in the polymer jet was measured. Shear viscosity, surface tension, relaxation time, and the electric conductivity and permittivity were measured as well. For this purpose different solutions of polyethylene oxide (PEO), polyacrylic acid (PAA), polyvinyl alcohol (PVA), polyurethane (PU) and polycaprolactone (PCL) were prepared and underwent electrospinning. The governing parameters investigated were the applied voltage ðVÞ; the solution flow rate ðQÞ; the polymer weight concentration ðCÞ; the molecular weight of the polymer ðMÞ; the nozzle-to-ground distance ðHÞ and, in some solutions, the concentration of ethanol ðCetÞ: q 2004 Elsevier Ltd. All rights reserved.

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Topics: Electrospinning (66%), Nanofiber (55%), Polyacrylic acid (53%) ...read more

898 Citations


Journal ArticleDOI: 10.1016/S0168-3659(02)00127-X
Abstract: Polyvinyl alcohol (PVA) is the most commonly used emulsifier in the formulation of poly lactide and poly ( d , l -lactide-co-glycolide) (PLGA) polymeric nanoparticles. A fraction of PVA remains associated with the nanoparticles despite repeated washing because PVA forms an interconnected network with the polymer at the interface. The objective of this study was to determine the parameters that influence the amount of residual PVA associated with PLGA nanoparticles and its effect on the physical properties and cellular uptake of nanoparticles. Nanoparticles were formulated by a multiple emulsion-solvent evaporation technique using bovine serum albumin (BSA) as a model protein. The parameters that affected the amount of residual PVA include the concentration of PVA and the type of organic solvent used in the emulsion. The residual PVA, in turn, influenced different pharmaceutical properties of nanoparticles such as particle size, zeta potential, polydispersity index, surface hydrophobicity, protein loading and also slightly influenced the in vitro release of the encapsulated protein. Importantly, nanoparticles with higher amount of residual PVA had relatively lower cellular uptake despite their smaller particle size. It is proposed that the lower intracellular uptake of nanoparticles with higher amount of residual PVA could be related to the higher hydrophilicity of the nanoparticle surface. In conclusion, the residual PVA associated with nanoparticles is an important formulation parameter that can be used to modulate the pharmaceutical properties of PLGA nanoparticles.

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Topics: PLGA (54%), Polyvinyl alcohol (52%)

864 Citations


Journal ArticleDOI: 10.1002/JBM.B.32694
Abstract: Polyvinyl alcohol (PVA) is a synthetic polymer derived from polyvinyl acetate through partial or full hydroxylation. PVA is commonly used in medical devices due to its low protein adsorption characteristics, biocompat- ibility, high water solubility, and chemical resistance. Some of the most common medical uses of PVA are in soft contact lenses, eye drops, embolization particles, tissue adhesion barriers, and as artificial cartilage and meniscus. The pur- pose of this review is to evaluate the available published information on PVA with respect to its safety as a medical device implant material for cartilage replacement. The review includes historical clinical use of PVA in orthopedics, and in vitro and in vivo biocompatibility studies. Finally, the safety recommendation involving the further development of PVA cryogels for cartilage replacement is addressed.

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Topics: Polyvinyl alcohol (52%), Low protein (51%)

688 Citations


Patent
24 Apr 2003-
Abstract: The present invention provides a dissolvable medical sealing device (3, 4; 6, 7; 9) for closing a wound in vessel. A sealing device (3, 4; 6, 7; 9) according to the invention is made of a material that dissolves by means of physical processes, rather than by means of chemical or biological processes. Such a sealing device (3, 4; 6, 7; 9) can be made of polyethylene glycol, polypropylene glycol, copolymers containing ethylene glycol and propylene glycol, polyvinyl alcohol or polyvinyl pyrolidone, or any combinations thereof.

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Topics: Polypropylene glycol (68%), Ethylene glycol (63%), Polyethylene glycol (55%) ...read more

670 Citations


Journal ArticleDOI: 10.1016/0166-6622(86)80340-7
E.D. Goddard1Institutions (1)
Abstract: This chapter describes Polymer-Surfactant reaction in systems comprising an uncharged water-soluble polymer and a charged synthetic surfactant. T. G. Jones illustrated the elegant simplicity of the surface tension method when applied to a mixture of a highly surface-active species, the surfactant, and a feebly surface-active species, the polymer. In a 1957 paper, S. Saito showed that considerable increases in the viscosity of methylcellulose and polyvinyl pyrrolidone (PVP) solutions can be brought about by the addition of sodium dodecyl sulfate (SDS), presumably due to a combination of electrical charging and attendant conformational effects. A similar intermediate transition in the specific conductivity/SDS concentration plot, showing the same weak dependence on polymer concentration, has been reported by N. W. Fadnavis and co-workers for mixed SDS solutions with PVP and with two grades of polyvinyl alcohol. Ultracentrifugation experiments were carried out by J. Francois on a high-molecular-weight polyethylene oxide specimen, in the presence and absence of SDS.

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Topics: Polyvinyl alcohol (54%), Pulmonary surfactant (54%), Sodium dodecyl sulfate (53%) ...read more

632 Citations


Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202229
2021619
2020840
20191,115
20181,151
20171,199

Top Attributes

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Topic's top 5 most impactful authors

Martin Steuer

21 papers, 127 citations

Anil Kumar Bajpai

19 papers, 534 citations

Fujiwara Naoki

18 papers, 54 citations

Takuji Okaya

17 papers, 209 citations

Takanori Isozaki

16 papers, 229 citations

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