Topic
Potassium dichromate
About: Potassium dichromate is a research topic. Over the lifetime, 1430 publications have been published within this topic receiving 18967 citations. The topic is also known as: Potassium dichromate(VI) & Chromium potassium oxide.
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TL;DR: Eight inorganic metal compounds were tested for their cytotoxic effect on an established hamster fibroblast line in vitro using a cell detachment assay and two different growth assays, the cloning effieciency and the cell number after 2 days subconfluent culture as parameters as parameters.
Abstract: Eight inorganic metal compounds (AlCl3, Al(OH)3 gel, Al(OH)3 salt, SnCl2, ZnSO4, K2Cr2O7, CdCl2, HgCl2) were tested for their cytotoxic effect on an established hamster fibroblast line (BHK-21/C13) in vitro using a cell detachment assay and two different growth assays, the cloning efficiency and the cell number after 2 days subconfluent culture as parameters. The test conditions for these assays were optimized, including incubation period, application of test substance, growth conditions and data analysis. Aluminum, zinc and tin compounds showed low cytotoxic effects when compared to potassium, cadmium and mercuric compounds. Potassium dichromate was highly toxic in both growth assays (0.0001-0.01 mM, with a clear dependency on the incubation time), whereas it proved to be only slightly toxic in the detachment assay (0.1-5 mM). Cadmium and mercuric chlorides were the most toxic compounds in the growth (0.00001-0.001 mM) and the cell detachment assays (0.01-0.1 mM). Variable incubation periods barely affected the cytotoxicity of mercuric chloride. Ranking of these cytotoxicity data was found to be identical to the ranking of LD50 values (oral, rat) as well as to the ranking according to threshold limit values for human workroom environment, and of human eye irritation data.
31 citations
TL;DR: Penicillium sp. mycelium can accumulate Pb from aqueous solutions of nitrate as mentioned in this paper, but the maximum quantity bound remained unchanged, even after heat treatment.
Abstract: Penicillium sp. mycelium can accumulate Pb from aqueous solutions of nitrate. Uptake of Pb by mycelial preparations after heat treatment was more rapid, but the maximum quantity bound remained unchanged. Chromium was not accumulated from solutions of potassium dichromate unless the mycelial preparation was first incubated in Pb nitrate. In the example given, 0.14 g of dry mycelium incubated in Pb nitrate (50 ppm, 2 hr) contained 850 gg of Pb and subsequently accumulated 120 μg of Cr in 5 min from 20 mL of 20 ppm dichromate solution.
30 citations
TL;DR: The data indicate that plasma reduction capacity is enhanced by a recent meal, but may be overwhelmed at Cr( VI) concentrations between 2000 and 10,000 micrograms/L, and that the rate of Cr(VI) uptake into RBCs may not exceed the rates of intracellular reduction at these concentrations.
30 citations
TL;DR: Phospholipids may be preserved for study in paraffin sections by fixing the tissue 1 to 3 days at room temperature in 2.5% potassium dichromate dissolved in 5% mercuric chloride.
Abstract: Phospholipids may be preserved for study in paraffin sections by fixing the tissue 1 to 3 days at room temperature in 2.5% potassium dichromate dissolved in 5% mercuric chloride. After this dichromate-sublimate fixative and paraffin embedding, the phospholipids are readily stained with Sudan black.
30 citations
TL;DR: Oral vitamin E administration has a hepatoprotective role against K2Cr2O7-induced hepatotoxicity in rats and resulted in normal hepatic histological and cellular contents.
30 citations