Topic
Potassium dichromate
About: Potassium dichromate is a research topic. Over the lifetime, 1430 publications have been published within this topic receiving 18967 citations. The topic is also known as: Potassium dichromate(VI) & Chromium potassium oxide.
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TL;DR: It is concluded from present study that potassium dichromate and magnesium sulphate causes oxidative stress by generation of reactive oxygen species (ROS) and causing DNA damage in testicular cells leading to adverse reproductive abnormalities.
Abstract: Objective To investigate the potential harmful effects of potassium dichromate and magnesium sulphate causing oxidative stress and reproductive toxicity in adult male mice model. Methods The experimental work was conducted on sixty male mice (Mus musculus) divided into three groups. Mice in group B and C received potassium dichromate and magnesium sulphate of 5.0 and 500 mg/Kg body weight/ml respectively, for sixty days. The blood sample was analyzed to assess oxidative stress and cellular damage. Results RESULTS showed high malondialdehyde (MDA) and low levels of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] in both potassium dichromate and magnesium sulphate administrated groups as compared to control group. Reduced number of sperm count and excessive destruction of testicular follicles, including destruction of spermatids, leydig cells and sertoli cells, were also seen in both groups. Conclusion We concluded from present study that potassium dichromate and magnesium sulphate causes oxidative stress by generation of reactive oxygen species (ROS) and causing DNA damage in testicular cells leading to adverse reproductive abnormalities.
16 citations
01 Jan 2012
TL;DR: In this paper, an attempt was made to evaluate chronic effect of Potassium dichromate on Daphnia magna, semi-statically, based on the results of an acute immobilisation study (48 hour EC50).
Abstract: An attempt was made to evaluate chronic effect of Potassium dichromate on Daphnia magna, semi-statically. Based on the results of an acute immobilisation study (48 hour EC50), the test item concentrations of 0.03, 0.05, 0.1, 0.2 and 0.4 mg/L of Potassium dichromate was selected for the chronic investigation. During the study, physico-chemical parameters of M4 medium were recorded and maintained within the range as stated in the OECD guideline no.211 and the validity criteria were met during the study. Based on the results, the EC50 of Potassium dichromate (based on % inhibition of reproduction) was determined as 0.19 mg/L with 95% confidence limits of 0.16 0.22 mg/L. The NOEC and LOEC were determined as 0.05 and 0.1 mg/L. Based on number of offspring reproduced, the NOEC and LOEC were determined as 0.03 and 0.05 mg/L, respectively. Based on survival of parental animal, the EC50 of Potassium dichromate was determined as 0.20 mg/L with 95% confidence limits of 0.15 0.24 mg/L. The NOEC and LOEC were determined as 0.1 and 0.2 mg/L, respectively. There is no published data available in the public domain for chronic effect of Potassium dichromate to Daphnia magna. The data on Potassium dichromate is an important prerequisite for test laboratories because it is used as reference test item for acute and reproduction studies to validate the test. Hence, an attempt was made to generate data for the Potassium dichromate under laboratory conditions.
15 citations
TL;DR: No support could be found for the hypothesis that mastitis, as evidenced by increased leucocyte counts in milk, is accompanied by an increase in lysozyme activity, and the sensitivity of ly sozyme to heat was demonstrated.
15 citations
TL;DR: The results speak against that cobalt chloride and potassium dichromate are un specific mitogens for human lymphoid cells, while an unspecific mitogenic effect is indicated for nickel sulfate.
Abstract: The metal allergens cobalt chloride, nickel sulfate and potassium dichromate were tested for the ability to give a mitogenic response in human thymocytes, both unseparated and Percoll-separated, inclu
15 citations
TL;DR: In this paper, a synergistic interference has been observed with the determination of aluminium by electrothermal atomic absorption spectrometry when phosphorus is present in the sample along with alkali or alkaline earth metals.
Abstract: Brain tissue is rich in phosphorus and alkali and alkaline earth metals. A synergistic interference has been observed with the determination of aluminium by electrothermal atomic absorption spectrometry when phosphorus is present in the sample along with alkali or alkaline earth metals. For the determination of aluminium in human brain samples, potassium dichromate was found to be an effective chemical modifier. The concentration of aluminium in National Institute of Standards and Technology (NIST) Standard Reference Materials (SRMs) Citrus Leaves (SRM 1572), Oyster Tissue (SRM 1566a) and in National Institute for Environmental Studies (NIES) Certified Reference Material (CRM) No. 6 Mussel were determined. Values of 76.6 ± 4.2, 86.8 ± 0.5 and 55.5 ± 10.1 µg g–1 were obtained before the use of the modifier, and 88.2 ± 6.2, 197.7 ± 6.8 and 215.0 ± 12.5 µg g–1 after the use of potassium dichromate as chemical modifier for Citrus Leaves, Oyster Tissue and Mussel, respectively. The concentrations of aluminium determined with the use of potassium dichromate as chemical modifier are in good agreement with the certified values in the standard samples. The aluminium contents of several human brain samples were also determined. Values ranged from 6.2 to 9.8 µg g–1 of aluminium (dry mass basis).
15 citations