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Precancerous condition

About: Precancerous condition is a research topic. Over the lifetime, 223 publications have been published within this topic receiving 5112 citations. The topic is also known as: precancerous condition & Precancerous Condition.


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Journal ArticleDOI
TL;DR: Evidence is presented that submucous fibrosis may be considered an important precancerous condition in Southeast Asia.

446 citations

Journal ArticleDOI
TL;DR: The criteria for grading Dysplasia in gastric epithelium into mild, moderate, and severe grades are given, and attention is drawn to the problems of differentiating inflammatory or regenerative change from mild dysplasia and intramucosal carcinoma from severe dyspl Asia.
Abstract: A distinction can be made between a precancerous condition and a precancerous lesion. The former is a clinical state associated with a significantly increased risk of cancer, whereas a precancerous lesion is a histopathological abnormality in which cancer is more likely to occur than in its apparently normal counterpart. Up to the present time atrophic gastritis, gastric ulcer, pernicious anaemia, gastric stumps, gastric polyps, and Menetrier's disease have all been considered as precancerous conditions and lesions of the stomach. Of these, only atrophic gastritis, pernicious anaemia, gastric stumps, and certain types of gastric polyp can now be regarded as having any really significant malignant potential. The precancerous lesion common to these is epithelial dysplasia which can occur in ordinary (foveolar) gastric epithelium as well as in intestinal metaplasia. The criteria for grading dysplasia in gastric epithelium into mild, moderate, and severe grades are given, and attention is drawn to the problems of differentiating inflammatory or regenerative change from mild dysplasia and intramucosal carcinoma from severe dysplasia. The clinical and epidemiological implications of gastric dysplasia are discussed with suggestions for further research.

437 citations

Journal ArticleDOI
TL;DR: CpG methylation around the promoter region, which increases during the progression from a precancerous condition to HCC, may participate in hepatocarcinogenesis through reduction of E‐cadherin expression, resulting in loss of intercellular adhesiveness and destruction of tissue morphology.
Abstract: Our study was designed to clarify the significance of silencing the E-cadherin gene, which is located on 16q22.1, due to CpG methylation during hepatocarcinogenesis. The CpG methylation status of primary hepatocellular carcinomas (HCCs) and corresponding liver tissues showing chronic hepatitis or cirrhosis, which are widely considered to be precancerous conditions, were assessed by digesting DNA with methylation-sensitive and non-sensitive restriction enzymes. CpG methylation around the promoter region of the E-cadherin gene was detected in 46% of liver tissues showing chronic hepatitis or cirrhosis and 67% of HCCs examined. Immunohistochemical examination revealed reduced E-cadherin expression in 59% of HCCs examined. CpG methylation around the promoter region correlated significantly with reduced E-cadherin expression in HCCs (p < 0.05). CpG methylation around the promoter region, which increases during the progression from a precancerous condition to HCC, may participate in hepatocarcinogenesis through reduction of E-cadherin expression, resulting in loss of intercellular adhesiveness and destruction of tissue morphology.

255 citations

Journal ArticleDOI
TL;DR: The hypothesis that submucous fibrosis is a precancerous condition was reinforced, based on observations of 89 patients with the disease in Ernakulam District, Kerala, India, where malignant transformation and coexistence together, oral cancer was observed in 13% of the present material.
Abstract: An evaluation of the malignant potential of submucous fibrosis, based on observations of 89 patients with the disease in Ernakulam District, Kerala, India was done. Out of the 89 patients, 12 were referred patients and 77 were diagnosed in population based studies. At the time of first examination oral cancer was found to be coexistent in nine (10%) cases. For 66 patients follow-up observations ranging from 4 to 15 yr (median 8 yr) were available. During this period malignant transformation was observed in three patients (4.5%). Considering malignant transformation and coexistence together, oral cancer was observed in 13% of the present material. Leukoplakia was found in 26% of the patients with submucous fibrosis. Out of 42 submucous fibrosis patients biopsied, 12% showed squamous cell carcinoma, 26% epithelial dysplasia, and 76% atrophic epithelium. These findings reinforced the hypothesis that submucous fibrosis is a precancerous condition.

184 citations

Journal ArticleDOI
TL;DR: The presence of an intact T4SS allows H. pylori to colonize the gastric corpus, which results in atrophic corpus-dominant gastritis, a severe precancerous condition, thus highlighting T4 SS and CagA as major risk factors for gastric cancer development.

179 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202311
202227
20218
20208
20196
20184