Topic
Pregnancy
About: Pregnancy is a research topic. Over the lifetime, 163969 publications have been published within this topic receiving 4013502 citations. The topic is also known as: pregnancy & gestation.
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TL;DR: Maternal mortality in parturients with PAH remains prohibitively high, despite lower death rates than previous decades, and early advice on pregnancy risks, including contraception, remains paramount.
Abstract: Pregnancy in women with pulmonary arterial hypertension (PAH) is considered to be associated with prohibitive maternal mortality During the past decade, new advanced therapies for PAH have emerged and progress in high-risk pregnancy management has been made We examined whether these changes have improved outcomes in parturients with PAH A systematic review of all cases of parturients with idiopathic pulmonary hypertension (iPAH), congenital heart disease associated with PAH (CHD-PAH), or PAH of other aetiology (oPH) published in the past decade (1997-2007) was performed Outcome data from this study were then compared with relevant data published between 1978 and 1996 Forty-eight case reports or case series met the inclusion criteria, totalling 73 parturients with PAH Seventy-two per cent of patients with iPAH were receiving advanced therapies, compared with 52% of CHD-PAH and 47% of oPH Although a publication bias cannot be excluded, overall maternal mortality was significantly lower compared with previous era (25 vs 38%, P = 0047) and was 17% in iPAH, 28% in CHD-PAH, and 33% in oPH Seventy-eight per cent of deaths occurred within the first month after delivery Primigravidae and parturients who received general anaesthesia were at higher risk of death (OR 370, 95% CI 115-125, P = 003 and OR 437, 95% CI 128-1650, P = 002, respectively) Maternal mortality in parturients with PAH remains prohibitively high, despite lower death rates than previous decades Early advice on pregnancy risks, including contraception, remains paramount Women with PAH who become pregnant warrant a multidisciplinary approach with consideration of advanced therapies
480 citations
TL;DR: Results of controlled studies indicate that the deficit can be met by supplementation, but inadequacies in health care delivery systems have limited the effectiveness of larger-scale interventions and iron fortification offers the most cost-effective option for the future.
480 citations
TL;DR: It is concluded that microbiologic screening in early pregnancy may aid in the assessment of patient risk for preterm delivery and the presence of various vaginal pathogens in earlyregnancy was associated with the subsequent development of premature rupture of membranes or preterm labor.
479 citations
TL;DR: High rates of gestational weight gain, especially early in pregnancy, may increase a woman's risk of GDM, and the association was stronger in overweight or obese and nonwhite women.
479 citations
TL;DR: Clinical history, including previous abnormal pregnancy history, birth of a large baby, maternal obesity, and family history of diabetes, is demonstrated to be an insensitive screening factor in the selection of gestational diabetic patients.
479 citations