Topic
Pregnancy
About: Pregnancy is a research topic. Over the lifetime, 163969 publications have been published within this topic receiving 4013502 citations. The topic is also known as: pregnancy & gestation.
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TL;DR: An important role for hypersecretion of LH before conception in miscarriage is indicated, and this finding offers the possibility of a simple predictive test for women before pregnancy, and could also be used to identify patients with an endocrine abnormality that can be remedied.
441 citations
TL;DR: The Diabetes in Early Pregnancy Study showed that good maternal control was associated with normal neurodevelopmental outcome and there is a significant transmission rate of 2% of type I diabetes if the mother has insulin-dependent diabetic mother, whereas the rate is 6% for the father.
441 citations
TL;DR: Recall of pregnancy-related events from thirty or more years ago is both reproducible and accurate for many factors related to pregnancy and delivery.
Abstract: We assessed the reproducibility and validity of a questionnaire that asks mothers to recall pregnancy-related events from thirty or more years ago Among 146 women who completed the questionnaire twice, responses were highly reproducible for pre-pregnancy height and weight (r = 095), pregnancy complications (r = 074), substance use (r = 080), preterm delivery (r = 082), birthweight (r = 094), and breastfeeding (r = 089) Among 154 women whose questionnaire responses were compared to data collected during their pregnancies, recall was highly accurate for height (r = 090), pre-pregnancy weight (r = 086), birthweight (r = 091), and smoking (sensitivity = 086, specificity = 094) These findings suggest that long-term maternal recall is both reproducible and accurate for many factors related to pregnancy and delivery
441 citations
TL;DR: Pre-eclampsia is a major cause of maternal mortality and morbidity, preterm birth, perinatal death, and intrauterine growth restriction, and the pathophysiology of this multisystem disorder is still unclear.
Abstract: The incidence of pre-eclampsia ranges from 3% to 7% for nulliparas and 1% to 3% for multiparas. Pre-eclampsia is a major cause of maternal mortality and morbidity, preterm birth, perinatal death, and intrauterine growth restriction. Unfortunately, the pathophysiology of this multisystem disorder, characterized by abnormal vascular response to placentation, is still unclear. Despite great polymorphism of the disease, the criteria for pre-eclampsia have not changed over the past decade (systolic blood pressure >140 mmHg or diastolic blood pressure ≥90 mmHg and 24-hour proteinuria ≥0.3 g). Clinical features and laboratory abnormalities define and determine the severity of pre-eclampsia. Delivery is the only curative treatment for pre-eclampsia. Multidisciplinary management, involving an obstetrician, anesthetist, and pediatrician, is carried out with consideration of the maternal risks due to continued pregnancy and the fetal risks associated with induced preterm delivery. Screening women at high risk and preventing recurrences are key issues in the management of pre-eclampsia.
440 citations
TL;DR: Control analyses showed that none of these effects was attributable to any of 37 potential confounding variables, including socioeconomic status, maternal age, smoking during pregnancy, and exposure to polybrominated biphenyls.
439 citations