Topic
Pregnenolone
About: Pregnenolone is a research topic. Over the lifetime, 3539 publications have been published within this topic receiving 126444 citations. The topic is also known as: (3b)-3-hydroxy-Pregn-5-en-20-one & 3-Hydroxypregn-5-en-20-one.
Papers published on a yearly basis
Papers
More filters
TL;DR: Results from the synthesis of 20R-20-t-Butyl-5-pregnene-3β,20-diol form the basis of a new hypothesis for the pathways used for the biosynthesis of pregnenolone from cholesterol, and two mechanisms consistent with these findings are proposed.
51 citations
TL;DR: While one gene product is highly expressed in testicular Leydig cells, and probably adrenal and ovary, accounting for their 3β-HSD content, a 3β,HSD is also expressed in liver in a sex-specific manner.
51 citations
TL;DR: The results can divide these analogs into HPV-enhancing and HPV-nonenhancing groups and accordingly impact the relative risk of individual oral contraceptive ingredient in cervical carcinogenesis.
51 citations
TL;DR: In this article, the effect of chronic experimental encephalomyelitis (EAE) on neuroactive steroid levels in the brain was investigated in both male and female rats, and it was shown that chronic EAE results in sex and regional specific alterations in the levels of neuroactive steroids in brain which are in many cases different to those produced by acute EAE.
Abstract: Our previous observations have shown that neuroactive steroid levels in the brain are affected by acute experimental autoimmune encephalomyelitis (EAE) with sex and regional specificity (Giatti et al. 2010). To better understand the effect of EAE on neuroactive steroids, we have here assessed the levels of pregnenolone, progesterone and its derivatives (i.e. dihydroprogesterone, tetrahydroprogesterone and isopregnanolone), testosterone and its derivatives (dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol) in different CNS regions of male and female rats affected by chronic EAE. Data obtained by liquid chromatography tandem mass spectrometry revealed that chronic EAE results in sex and regional specific alterations in the levels of neuroactive steroids in the brain, which are in many cases different to those produced by acute EAE. The specific changes in neuroactive steroid levels after chronic EAE may be of relevance to design new possible therapeutic strategies for the disease.
51 citations
TL;DR: In this article, a human cholesterol 7 alpha-hydroxylase, expressed as a recombinant in Escherichia coli and COS cells, was found to be active toward 20(S)-hydroxy cholesterol, 25-hydroxycholesterol, and 27-hydoxycholesterol.
51 citations