Topic
Pregnenolone
About: Pregnenolone is a research topic. Over the lifetime, 3539 publications have been published within this topic receiving 126444 citations. The topic is also known as: (3b)-3-hydroxy-Pregn-5-en-20-one & 3-Hydroxypregn-5-en-20-one.
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TL;DR: One of the main functions of the Ca2+ messenger is to increase cholesterol supply to the P450 side chain cleavage enzyme by enhancing endogenous intermembrane cholesterol transfer to a mitochondrial site containing the enzymes responsible for the initial steps of the steroidogenic cascade.
51 citations
51 citations
TL;DR: It was shown that picogram to nanogram/ml amounts of these metabolites are present in all human sera and levels in men were comparable to those of women in the follicular phase of the menstrual cycle.
51 citations
TL;DR: Proteins which are immunochemically compatible with hepatic SCP2 appear to be present in steroidogenic tissues and may play a role in control of mitochondrial cholesterol side chain cleavage activity.
51 citations
TL;DR: In this paper, granulosa and thecal cells of ripening cow follicles were incubated in vitro in the presence of different steroid precursors involved in the Δ 4 and Δ 5 -pathway.
51 citations