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Pregnenolone

About: Pregnenolone is a research topic. Over the lifetime, 3539 publications have been published within this topic receiving 126444 citations. The topic is also known as: (3b)-3-hydroxy-Pregn-5-en-20-one & 3-Hydroxypregn-5-en-20-one.


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Journal ArticleDOI
TL;DR: In this article, the effects of i.p. administration of neurosteroids, allopregnanolone and pregnenolone sulfate, were studied in WAG/Rij rats, a genetic model for generalized absence epilepsy.

41 citations

Journal ArticleDOI
TL;DR: The Steroidogenic Acute Regulatory protein has been shown to have an indispensable role in acute steroid production and is proposed to be this labile protein factor, which is required for the intramitochondrial translocation of cholesterol.
Abstract: The rate-limiting and acutely regulated step in steroid hormone biosynthesis is the translocation of cholesterol, the precursor of all steroid hormones, from the mitochondrial outer membrane to the inner membrane, where it is converted to pregnenolone by the cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc). This step has long been known to be dependent upon the de novo synthesis of a labile protein factor, which is required for the intramitochondrial translocation of cholesterol. Recently, the Steroidogenic Acute Regulatory (StAR) protein has been shown to have an indispensable role in acute steroid production and is proposed to be this labile protein factor. Given the fundamental importance of StAR as a key regulator of steroid hormone biosynthesis, the next frontier for researchers is elucidating the molecular mechanisms that control StAR expression and function.

41 citations

Journal ArticleDOI
TL;DR: Under similar conditions, but in the presence of a cytochrome P 450 solubilized from rat liver mitochondria, cholesterol was transformed into a more polar compound tentatively identified as 26-hydroxycholesterol.

41 citations

Journal ArticleDOI
TL;DR: The results indicate that hyperglycemia induced by streptozotocin is not inconsistent with production of an LH surge or with ovulation following ovarian stimulation by PMS, but the lowered production of progesterone appears to be a primary factor in the reduced ovulatory rate.
Abstract: Immature female rats were injected with streptozotocin (60 mg/kg, iv) 3 to 4 days prior to the injection (iv) of 20 IU of pregnant mare's serum gonadotropin (PMS). Animals were killed at various intervals and the serum levels of estradiol, luteinizing hormone (LH), and progesterone were determined by radioimmunoassays. The ovarian steroid 17α-hydroxylase activity was determined by a tritium exchange assay using pregnenolone as the substrate. Ovulation was determined 72 hr after PMS by flushing of the oviducts. The diabetes mellitus induced by the drug reduced the number of animals ovulating and in some animals the number of ova shed when compared to controls. However, a surge in LH, which reached a peak at 60 hr, was seen in the diabetic animals; a larger peak with the same timing was found in the controls. Changes in ovarian 17α-hydroxylase also indicated that an increase in LH release occurred in the diabetic animals at about 60 hr. Estradiol levels were higher, but progesterone levels lower, in...

41 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202344
202255
202124
202028
201950
201835