Topic
Pregnenolone
About: Pregnenolone is a research topic. Over the lifetime, 3539 publications have been published within this topic receiving 126444 citations. The topic is also known as: (3b)-3-hydroxy-Pregn-5-en-20-one & 3-Hydroxypregn-5-en-20-one.
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TL;DR: Urinary steroids from a patient with 17α-Hydroxylase deficiency syndrome have been identified and it is probable that the 11-oxygenated 21-deoxysteroids are principally formed by microbial 21- dehydroxylation of the tetrahydro metabolites of corticosterone secreted into the bile.
39 citations
TL;DR: Extended in vivo treatment with testosterone decreased the expression of Scarb1 (scavenger receptor class B type 1), Tspo (translocator protein), Star (steroidogenic acute regulatory protein), Cyp11a1 (cholesterol side-chain cleavage enzyme), and Cyp17a1
39 citations
TL;DR: It is concluded that pregnenolone sulfate acts through a Gi/o-coupled sigma1-like receptor to enhance short-term presynaptic facilitation onto adult hippocampal CA1 neurons.
39 citations
TL;DR: Using mass spectrometric, radioisotopic, chromatographic and chemical techniques, five fatty acid esters of 3 beta-hydroxy-5-pregnancy-20-one (pregnenolone) have been identified as components of the lipoidal derivatives biosynthesized in vitro with bovine adrenal mitochondria.
39 citations
TL;DR: It appears that administration of human menopausal gonadotropin early (day 1) in the follicular phase results in incomplete maturation of the granulosa cells, and the optimal oocyte, in terms of successful fertilization, may be one derived from a follicle that has undergone appropriate stimulation resulting in adequate maturation, but has not surpassed that point.
Abstract: The production of 17β-estradiol and progesterone (Prog) by human granulosa-luteal cells obtained from 24 aspirated follicles of 11 women undergoing laparoscopy in an in vitro fertilization program was studied. Follicular growth was stimulated with an individualized human menopausal gonadotropin regimen begun on either day 1 (group I; n = 5) or day 3 (group II; n = 6) of the menstrual cycle, and laparoscopy was performed 36 h after hCG administration. Granulosa-luteal cells were cultured for 2 h in culture medium alone or in the presence of either pregnenolone (10−7 M) or testosterone (10−7 M). Aromatase activity was present in the granulosa-luteal cells, as evidenced by a significant (P < 0.001) increase in E2 production in the presence of testosterone. The addition of pregnenolone did not augment Prog production. Granulosa-luteal cells derived from Group II patients produced significantly (P < 0.001) more Prog than those derived from group I patients. In addition, group II granulosa-luteal cells...
39 citations