scispace - formally typeset
Search or ask a question
Topic

Primate

About: Primate is a research topic. Over the lifetime, 1250 publications have been published within this topic receiving 67388 citations. The topic is also known as: the primate order & primates.


Papers
More filters
Journal ArticleDOI
TL;DR: In this article , the feasibility and efficiency of the surgical approach and vector delivery in a nonhuman primate model was reported, where five rhesus macaques were injected with AAV1 or Anc80L65 expressing eGFP using a transmastoid posterior tympanotomy approach to access the round window membrane.
Abstract: Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate hearing and balance disorders. We previously established the benefits of Anc80L65 in targeting inner and outer hair cells in newborn mice. To accelerate translation to humans, we now report the feasibility and efficiency of the surgical approach and vector delivery in a nonhuman primate model. Five rhesus macaques were injected with AAV1 or Anc80L65 expressing eGFP using a transmastoid posterior tympanotomy approach to access the round window membrane after making a small fenestra in the oval window. The procedure was well tolerated. All but one animal showed cochlear eGFP expression 7-14 days following injection. Anc80L65 in 2 animals transduced up to 90% of apical inner hair cells; AAV1 was markedly less efficient at equal dose. Transduction for both vectors declined from apex to base. These data motivate future translational studies to evaluate gene therapy for human hearing disorders.

16 citations

Journal ArticleDOI
TL;DR: These findings suggest that the coexistence of the two taxa is facilitated via differential macrohabitat use and spatial avoidance, and that divergent habitat-use strategies may reflect interspecific competition, they may also merely reflect different physiological or ecological requirements.
Abstract: Here we provide a preliminary assessment of dietary and habitat requirements of two sympatric primate taxa, a "simple-stomached" and "complex-stomached" species (Rhinopithecus bieti Colobinae vs. Macaca mulatta Cercopithecinae), as a basis for illuminating how the two coexist. Of ca. 22 plant food species consumed by the macaques, at least 16 were also eaten by the snub-nosed monkeys. Both species showed a preference for fruits. While the snub-nosed monkeys did not utilize any resources associated with human communities, rhesus macaques did occasionally raid agricultural crops. The mean elevation of the snub-nosed monkey group was 3,218 m, while the mean elevation of the macaque group was 2,995 m. Macaques were also spotted on meadows whereas snub-nosed monkeys evidently avoided these. For both species, mixed deciduous broadleaf/conifer forest was the most frequently used ecotype, but whereas evergreen broadleaf forest (Cyclobalanopsis community) accounted for only 3% of the location records of the snub-nosed monkeys, it accounted for 36% of the location records of the macaques. Groups of the two species usually kept a considerable spatial distance from one another (mean 2.4 km). One close encounter and confrontation between groups of the two species resulted in the macaque group moving away. Our findings suggest that the coexistence of the two taxa is facilitated via differential macrohabitat use and spatial avoidance. Although divergent habitat-use strategies may reflect interspecific competition, they may also merely reflect different physiological or ecological requirements.

16 citations

Journal ArticleDOI
TL;DR: The two new species of pinworms from howler monkeys were morphologically distinct and formed reciprocally monophyletic lineages in molecular phylogenetic trees and suggest that the diversity of pinworm parasites from Neotropical primates might be underestimated.

16 citations

Journal ArticleDOI
TL;DR: Three polyspecific groups of free‐ranging macaques were observed in July and August of 1980 and 1981 in the forests of the New Territories of mainland Hong Kong, and all three groups contained hybrids between M. mulatta and M. fascicularis.
Abstract: Three polyspecific groups of free-ranging macaques were observed in July and August of 1980 and 1981 in the forests of the New Territories of mainland Hong Kong. Two groups were composed of rhesus monkeys (Macaca mulatta) and long-tailed or crab-eating monkeys (M. fascicularis), and one group was composed of both the former plus Japanese macaques (M. fuscata). All three groups contained hybrids between M. mulatta and M. fascicularis. This combination of species within the same social group is an unusual circumstance in natural habitats, and it offers a unique opportunity for field studies in primate ecology and behavior.

16 citations

Journal ArticleDOI
TL;DR: Analysis of the ε Ig gene reveals dramatic differences in the gene segment encoding the mε C terminal region among the four major primate lineages: the Strepsirhini primates, the tarsiers, New World monkeys, and Old World monkeys and apes/humans.
Abstract: Membrane-bound IgE (mIgE) on B lymphocytes is essential for IgE production. Earlier studies showed that the e chain of mIgE (me) on human B cells has a “long” isoform, with an extra “CemX” domain of 52 amino acid (aa) residues between the CH4 domain and the membrane-anchor segment, as compared to the conventional “short” isoform. Because CemX provides an antigenic site for targeting IgE-expressing B cells to down-regulate IgE production in patients with allergy, analysis of CemX in various animals is of great interest. Hence, we analyzed the e Ig gene, in particular, its membrane exon regions encoding the membrane anchor peptide segment and CemX domain, of 26 species of the order Primates and 12 species of seven non-Primate orders using data obtained experimentally or retrieved from GenBank. Our analyses reveal the unexpected finding that the genes of three extant tarsier species do not contain the membrane exons for mIgE. Another striking finding is that early evolved Strepsirhini primates such as lemurs and lorises do not have gene segments for the long isoform, whereas New World monkeys such as marmosets and squirrel monkeys allow the transcription of only the long isoform. In Old World monkeys and apes, including humans, the e gene allows the transcription of both isoforms. This work thus reveals the dramatic differences in the gene segment encoding the me C terminal region among the four major primate lineages: the Strepsirhini primates, the tarsiers, New World monkeys, and Old World monkeys and apes/humans.

16 citations


Network Information
Related Topics (5)
Offspring
26.6K papers, 874.3K citations
76% related
Animal ecology
30.8K papers, 1M citations
76% related
Visual cortex
18.8K papers, 1.2M citations
76% related
Foraging
19.8K papers, 708.7K citations
76% related
Natural selection
9.2K papers, 659.9K citations
76% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023296
2022585
202133
202033
201930
201842