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Prolactin

About: Prolactin is a research topic. Over the lifetime, 22356 publications have been published within this topic receiving 609537 citations. The topic is also known as: lactotropin, & PRL,.


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Journal ArticleDOI
TL;DR: It is concluded that physical training causes adaptive changes in highly trained runners so that identical GH and PRL responses to exercise are recorded at higher absolute workloads.
Abstract: The effect of acute exercise at three graded intensities on plasma growth hormone (GH) and prolactin (PRL) concentrations was examined in three groups of healthy male volunteers. According to their tr

137 citations

Journal ArticleDOI
TL;DR: The results indicate that the combination oral contraceptives have a direct effect upon the pituitary gland, causing an increase in prolactin release and a decrease in gonadotropin release.

137 citations

Journal ArticleDOI
TL;DR: This review discusses the possible physiological importance of milk contains a significant number of substances having peptide characteristics that are known to possess biological activity on suckling mammals after gastrointestinal administration.
Abstract: Milkcontains a significant number of sub stances having peptide characteristics that are known to possess biological activity. The possible physiological im portance for the neonate is discussed in this reviewin light of their effects (epidermal growth factor, nerve growth fac tor, insulin, prolactin, somatostatin, thyroid-releasing hor mone, thyroid-stimulating hormone, growth hormoneâ€"re leasing factor, luteinizing hormone-releasing hormone, adrenocorticotrophic hormone, erythropoietin, bombesin- like peptides, calcitonin, AŸ-casomorphinsand delta-sleep- peptides) on suckling mammals after gastrointestinal administration. J. Nutr. 119: 1543-1551, 1989.

137 citations

Journal ArticleDOI
TL;DR: Depressed patients have different types of abnormal 5-hydroxytryptamine-mediated neuroendocrine responses that correlate with the presence or absence of severe weight loss and cortisol hypersecretion, and these abnormalities are central to the depressive disorder or have implications for treatment response.
Abstract: • The increases in plasma levels of prolactin (PRL) and growth hormone (GH) following intravenous administration of the 5-hydroxytryptamine precursor tryptophan (100 mg/kg) were assessed in 30 depressed patients and 30 control subjects. In depressed patients who lost less than 10 lb, PRL responses were significantly reduced compared with controls. In contrast, the PRL responses of patients with weight loss exceeding 10 lb were significantly greater than those of either controls or the other depressed patients. Growth hormone responses to tryptophan were significantly decreased in patients who lost less than 10 lb. Prolactin, but not GH, responses correlated significantly with the postdexamethasone plasma cortisol concentration; however, an apparent relationship between GH and PRL responses and suicidal behavior was probably due to the common factor of weight loss. The results suggest that depressed patients have different types of abnormal 5-hydroxytryptamine—mediated neuroendocrine responses that correlate with the presence or absence of severe weight loss and cortisol hypersecretion. Further investigations are needed to establish if these abnormalities are central to the depressive disorder or have implications for treatment response.

137 citations

Journal ArticleDOI
TL;DR: This work focuses on providing an over-view of prolactin action during development of the model murine mammary gland, and hopes thatalgamation of these two aspects will increase the understanding of cell proliferation and differentiation within the mammary glands.
Abstract: Mammary morphogenesis is orchestrated with other reproductive events by pituitary-driven changes to the systemic hormone environment, initiating the formation of a mammary ductal network during puberty and the addition of secretory alveoli during pregnancy. Prolactin is the major driver of development during pregnancy via regulation of ovarian progesterone production (in many species) and direct effects on mammary epithelial cells (in all species). Together these hormones regulate two aspects of development that are the subject of intense interest: (1) a genomic regulatory network that integrates many additional spatial and temporal cues to control gene expression and (2), the activity of a stem and progenitor cell hierarchy. Amalgamation of these two aspects will increase our understanding of cell proliferation and differentiation within the mammary gland, with clear application to our attempts to control breast cancer. Here we focus on providing an over-view of prolactin action during development of the model murine mammary gland.

137 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023360
2022585
2021202
2020221
2019180
2018172