Topic
Prolactin
About: Prolactin is a research topic. Over the lifetime, 22356 publications have been published within this topic receiving 609537 citations. The topic is also known as: lactotropin, & PRL,.
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TL;DR: Oestrus suppression was induced in lesioned mice by haloperidol treatment which raises plasma prolactin, and oestrus returned some 72 h after withdrawal of haloperodol treatment.
Abstract: Mice were grouped to induce suppression of oestrus and subjected to removal of the vomeronasal organs or treatment with CB 154 which lowers prolactin levels. Both treatments overcame the suppression of oestrus after 72 h. Oestrus suppression was induced in lesioned mice by haloperidol treatment which raises plasma prolactin, and oestrus returned some 72 h after withdrawal of haloperidol treatment.
123 citations
TL;DR: When rat anterior pituitary was incubated at 37.5 C in a Dubnoff metabolic shaker for 2 hr, 169% more prolactin was found in the combined medium and AP than in nonincubated AP.
Abstract: When rat anterior pituitary (AP) was incubated at 375 C in a Dubnoff metabolic shaker for 2 hr, 169% more prolactin was found in the combined medium and AP than in nonincubated AP When AP was inc
123 citations
TL;DR: The dissociation of TSH and LH into two subunits raises a number of biological questions—for example, those concerning the control of biosynthesis of individual chains and the possible effects of releasing factors.
Abstract: Publisher Summary
This chapter describes the structure of thyrotropin and its relationship to luteinizing hormone (LH). The pituitary peptide hormones were among the first compounds to yield evidence for probable evolutionary relationships among proteins and peptides with different functions—that is, oxytocin and vasopressin; the corticotropins, melanotropins, and β-lipotropin; and more recently prolactin and growth hormone. The likelihood that follicle-stimulating hormone (FSH) contains subunits was recognized by Gray, and Papkoff and Ekblad reported that the FSH chain of LH may have common properties with a subunit of FSH. The dissociation of TSH and LH into two subunits raises a number of biological questions—for example, those concerning the control of biosynthesis of individual chains and the possible effects of releasing factors.
123 citations
TL;DR: It is demonstrated that PE are active in lactotroph cells of the pituitary, and the estrogenic effects of PE in PR1 cells were ER dependent, in that addition of the antiestrogen ICI-182,780 inhibited prolactin response.
123 citations
TL;DR: The synthetic replicate of a 44 amino acid peptide isolated from a human pancreatic tumor possesses high specific activity to release growth hormone (GH) in anesthetized male rats and serves as powerful tools with which to investigate the mechanisms of GH secretion.
123 citations