Topic
Prolactin
About: Prolactin is a research topic. Over the lifetime, 22356 publications have been published within this topic receiving 609537 citations. The topic is also known as: lactotropin, & PRL,.
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TL;DR: The patterns of prolactin secretion during the estrous cycle and pseudopregnancy were determined in rats bearing chronic aortic catheters from which blood samples were withdrawn at 2-hr intervals throughout both reproductive states.
Abstract: The patterns of prolactin secretion during the estrous cycle and pseudopregnancy were determined in rats bearing chronic aortic catheters from which blood samples were withdrawn at 2-hr intervals throughout both reproductive states. Prolactin concentrations were determined by radioimmunoassay. Except for the spontaneous proestrus surges observed at the beginning and end of the blood collection, plasma prolactin concentrations during the estrous cycle were low, never rising above 10 ng/ml. In pseudopregnant animals, prolactin concentrations were highly erratic but significantly elevated during the 24 hr period following cervical stimulation. Beginning on day 1 and at approximately 24-hr intervals thereafter through day 11, a surge of prolactin secretion occurred, beginning at 0100 hr, peaking at 0300–0500 hr and terminating by 0900–1100 hr. Maximal mean prolactin values during the surges ranged from 40–110 ng/ml. These daily nocturnal surges of pseudopregnancy alternate daily with a period from 1100 hr to ...
118 citations
Journal Article•
TL;DR: The data suggest that anovulatory cycles are correlated with the amount of exercise and increased levels of catechol estrogens, which may interact to suppress luteinizing hormone release at the hypothalamic pituitary axis.
118 citations
TL;DR: The findings on the membrane receptors in the human and rat prostate cancers raise the intriguing possibility that LH‐RH, acting as a growth factor, along with EGF and prolactin, might be involved in complex interactions that contribute to the promotion of prostate cancer in man.
Abstract: Using sensitive multipoint micromethods, we estimated membrane receptors for [D-Trp6]-luteinizing hormone-releasing hormone ([ D-Trp6]-LH-RH), somatostatin (SS-14), human prolactin (hPRL), and epidermal growth factor (EGF) in experimental Dunning rat prostate cancers and in samples of normal human prostate, benign prostatic hyperplasia (BPH), and human prostate cancer (PC) obtained from biopsy, after prostatectomy, or at autopsy. In the Dunning R-3327 rat prostate adenocarcinoma specimens, the receptors were characterized in untreated animals and following in vivo treatment with microcapsules of the agonist [D-Trp6]-LH-RH and the somatostatin analog RC-160. Two populations of binding sites were found for [D-Trp6]-LH-RH, one with high affinity and low capacity and another with low affinity and high capacity. Treatment with [D-Trp6]-LH-RH and RC-160 alone or with the combination of these analogs increased the binding capacity (Bmax) of the low-affinity binding sites for [D-Trp6]-LH-RH and decreased Bmax for hPRL and EGF. Therapy with [D-Trp6]-LH-RH also reduced Bmax of SS-14 binding and dissociation binding constant of high-affinity binding sites for [D-Trp6]-LH-RH, whereas administration of RC-160 or the combination treatment with both analogs increased Bmax of SS-14 binding. These findings are compatible with the view that analogs of LH-RH and SS-14 might exert some direct inhibitory effects on the Dunning prostate cancer. Among 13 human BPH samples examined, only one had receptors for [D-Trp6]-LH-RH, and seven specimens exhibited binding for prolactin. [D-Trp6]-LH-RH receptors were found in all seven samples of human PC but not in any of the eight specimens of normal human prostate. All samples of normal human prostate, BPH, and human PC exhibited binding sites for EGF but not for SS-14. Our findings on the membrane receptors in the human and rat prostate cancers raise the intriguing possibility that LH-RH, acting as a growth factor, along with EGF and prolactin, might be involved in complex interactions that contribute to the promotion of prostate cancer in man.
117 citations