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Prolactin

About: Prolactin is a research topic. Over the lifetime, 22356 publications have been published within this topic receiving 609537 citations. The topic is also known as: lactotropin, & PRL,.


Papers
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Journal ArticleDOI
04 Nov 1988-Cell
TL;DR: The structure of Pit-1 and its recognition elements suggests that metazoan tissue phenotype is controlled by a family of transcription factors that bind to related cis-active elements and contain several highly conserved domains.

941 citations

Book
01 Jan 1979
TL;DR: This ebooks is under topic such as a radioimmunoassay method for human pituitary luteinizing methods inRadioimmunOassay, toxicology, and springer, and a rapid radioIMmunoASSay method of (39161) ultrafiltration method for direct radioim Muncoassay measurement new solid phases for estimation of hormones by agreement between electrochemiluminescence and raciloimmunosynthesis.
Abstract: The best ebooks about Methods Of Hormone Radioimmunoassay that you can get for free here by download this Methods Of Hormone Radioimmunoassay and save to your desktop. This ebooks is under topic such as a radioimmunoassay method for human pituitary luteinizing methods in radioimmunoassay, toxicology, and springer a rapid radioimmunoassay method of (39161) ultrafiltration method for direct radioimmunoassay measurement new solid phases for estimation of hormones by agreement between electrochemiluminescence and raciloimmunoassay: principle and technique jpma parathyroid hormone: radioimmunoassay and clinical radioimmunoassay of plasma hormones: review of plasma examination of the tissue ghrelin expression of rats with 2 radioimmunoassay of gi hormones bprcem erroneous thyroid-stimulating hormone radioimmunoassay prolactin and luteinizing hormone cells of pregnant and a radioimmunoassay for rat ghrelin: evaluation of method luteinizing hormone-releasing hormone levels in human validation of nonradioactive chemiluminescent immunoassay general principles, problems, and interpretation in the radioimmunoassay and related techniques jpma radioimmunoassay for proparathyroid hormone hormone analysis ksu faculty member websites a rapid radioimmunoassay method for serum luteinizing radioimmunoassay of secretin rdspringer a radioimmunoassay for erythropoietin blood journal original article comparative study on determination of measurement of human luteinizing hormone jci comparison of solid-phase radioimmunoassay and competitive standard methods for physiology and biochemistry research radioimmunoassay measurement of secretin half-life in man radioimmunoassay and related procedures in medicine core methods in determining growth hormone concentrations: an serum prolactin levels in humans from birth to adult life efficacy of synthetic gonadotropin releasing hormone radioimmunoassay for the in-vitro determination of methods for assessing the effects of chemicals on the adaptation and analytical validation of a radioimmunoassay radioimmunoassay of human parathyroid hormone in development and validation of a solid-phase radioimmunoassay the embryo project encyclopedia use of in the radioimmunoassay human journal of clinical radioimmunoassay for luteinizing hormone in plasma or

925 citations

Journal ArticleDOI
TL;DR: This is the first time severe psychological stress has been shown to produce a measurable abnormality in immune function which is not obviously caused by hormonal changes.

897 citations

Journal ArticleDOI
TL;DR: The mammary gland factor, MGF, has been shown to be a central mediator in the lactogenic hormone response and the DNA binding activity of MGF is hormonally regulated and essential for beta‐casein promoter activity.
Abstract: Milk protein gene expression in mammary epithelial cells is regulated by the action of the lactogenic hormones insulin, glucocorticoids and prolactin. The mammary gland factor, MGF, has been shown to be a central mediator in the lactogenic hormone response. The DNA binding activity of MGF is hormonally regulated and essential for beta-casein promoter activity. We have used Red A Sepharose- and sequence-specific DNA affinity chromatography to purify MGF from mammary gland tissue of lactating sheep. Proteins of 84 and 92 kDa were obtained, proteolytically digested and the resulting peptides separated by reverse phase high pressure liquid chromatography. The 84 and 92 kDa proteins yielded very similar peptide patterns. The amino acid sequence of two peptides was determined. The sequence information was used to derive oligonucleotide probes. A cDNA library from the mRNA of mammary gland tissue of lactating sheep was screened and a molecular clone encoding MGF was isolated. MGF consists of 734 amino acids and has sequence homology with the 113 (Stat113) and 91 kDa (Stat91) components of ISGF3, transcription factors which are signal transducers of IFN-alpha/beta and IFN-gamma. Two species of MGF mRNA of 6.5 and 4.5 kb were detected in mammary gland tissue of lactating sheep. Lower mRNA expression was found in ovary, thymus, spleen, kidney, lung, muscle and the adrenal gland. MGF cDNA was incorporated into a eukaryotic expression vector and cotransfected with a vector encoding the long form of the prolactin receptor into COS cells. A strong MGF-specific bandshift was obtained with nuclear extracts of COS cells induced with prolactin. Treatment of activated MGF with a tyrosine-specific protein phosphatase resulted in the loss of DNA binding activity. Prolactin-dependent transactivation of a beta-casein promoter-luciferase reporter gene construct was observed in transfected cells.

821 citations

Journal ArticleDOI
TL;DR: It is shown, in a bird, that the hypothalamus also contains a novel peptide which inhibits gonadotropin release, the first hypothalamic peptide inhibiting gonadotropic hormone reported in a vertebrate.

760 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023360
2022585
2021202
2020221
2019180
2018172