Topic
Propylthiouracil
About: Propylthiouracil is a research topic. Over the lifetime, 2181 publications have been published within this topic receiving 46996 citations. The topic is also known as: Thyreostat® & 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone.
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TL;DR: That toxic reactions can occur from methimazole therapy, the newest of the antithyroid drugs, is attested to by the reports of several investigators, and a third such case is reported in which toxic hepatitis developed as an added complication.
Abstract: That toxic reactions can occur from methimazole therapy, the newest of the antithyroid drugs, is attested to by the reports of several investigators. 1 These reactions follow the same general pattern noted with the other antithyroids and include at least two instances of agranulocytosis. 2 We are here reporting a third such case in which toxic hepatitis developed as an added complication. REPORT OF A CASE A white woman, aged 62, who was to have a cataract removed from the left eye was referred to us in April, 1947, because of nervousness, excess sweating, and palpitation. She had had insomnia and a voracious appetite with weight loss during the previous six months. The thyroid showed bilateral nodular enlargement, there was lid-lag and manual tremor, and the basal metabolic rate was + 15%. Improvement followed after one month of therapy with 300 mg. propylthiouracil daily and was maintained for a second month
25 citations
TL;DR: The case of a 13-year-old girl who developed jaundice and profound liver dysfunction with rapid progression to metabolic encephalopathy while receiving PTU therapy and died despite extensive therapeutic measures, shows that in spite of regular monitoring, severe, rare, rapidly occurring complications ofPTU therapy may still occur.
Abstract: Propylthiouracil (PTU), a thyroid hormone inhibitor, is widely used for the treatment of hyperthyroidism. Rarely, the drug has been associated with severe hepatotoxicity. We present the case of a 13-year-old girl who developed jaundice and profound liver dysfunction with rapid progression to metabolic encephalopathy while receiving PTU therapy. She died despite extensive therapeutic measures including orthotopic liver transplantation. Her rapid clinical course and fatal outcome show that in spite of regular monitoring, severe, rare, rapidly occurring complications of PTU therapy may still occur.
25 citations
TL;DR: Data suggest that the protective effects of PTU against liver damage may be due to scavenging reactions with hydroxyl radicals in particular and/or its antioxidant potential.
25 citations
TL;DR: For the first time, it has been shown in vivo that propylthiouracil abolishes the ethanol‐induced increase in liver oxygen consumption that follows long‐term ethanol administration.
25 citations