Propylthiouracil

About: Propylthiouracil is a research topic. Over the lifetime, 2181 publications have been published within this topic receiving 46996 citations. The topic is also known as: Thyreostat® & 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone.

Time- and dose-dependent effect of triiodothyronine on submaxillary gland epidermal growth factor concentration in adult female mice.

Abstract: Previous studies have shown that thyroid hormones induced cytodifferentiation in immature and mature mouse submaxillary gland (SMG) and increase SMG concentrations of nerve growth factor and epidermal growth factor (EGF). These observations suggested that thyroid hormones increased SMG EGF synthesis. The following experiments were performed in order to determine the presence of specific nuclear T3 receptors in mouse SMG and the time and dose dependency of the SMG EGF response to a single injection of T3. In the first series of experiments, the presence of specific nuclear T3 receptors was established. The Ka of the receptor in SMG [0.60 ± 0.04 × 1010 M1 (mean ± SEM)] was similar to that observed in liver. The number of binding sites in SMG (46 ± 1 fmol/mg protein) was significantly less than in liver (266 ± 40 fmol/mg protein; P < 0.001). Induction of hypothyroidism in adult female mice by the administration of 0.1% propylthiouracil in their drinking water, led to a significant increase in the number of T...

Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism.

Abstract: We describe the ANCA profile of two monozygotic triplets (A and B) treated with propylthiouracil (PTU) for hyperthyroidism who developed LE-like manifestations. Triplet C also developed hyperthyroidism but was not treated with PTU and never experienced LE-like symptoms. Triplet A and B showed a marked rise in P-ANCA titer to 1:1280 after PTU was introduced whereas triplet C never had a titer higher than 1:80. Consecutive sera were investigated for ANCA to six different neutrophil granule proteins. Triplet A and B, but not C, both developed a strongly positive elastase-ANCA. Our results confirm the importance of a genetic factor influencing the susceptibility to drug-induced LE.

The effects of hypothalamic lesions on goitrogenesis and pituitary TSH secretion in the propylthiouracil-treated guinea pig.

Abstract: Propylthiouracil (PTU)-induced goitrogenesis was selectively impaired in male guinea pigs by anterior hypothalamic lesions. These lesions also reduced or abolished the PTU-induced enlargement of the adenohypophysis and the increase of thyrotrophin (TSH) stores therein, without causing gonad atrophy. Afore posterior lesions affected TSH secretion less and did cause gonad atrophy. The findings are interpreted to mean that neither the synthesis nor the release of TSH can reach maximal levels in the absence of the neural structures which were damaged. IN HATS, appropriate hypothalamic lesions have been found to impair, but not abolish, thyrotrophin (TSH) secretion (1–5). In dogs, on the other hand, similar lesions seem to eliminate TSH secretion, or at least its release phase, since they reduce both thyroid size and I131 uptake to hypophysectomy-like levels (6). This apparent species difference in the extentto which TSH secretion may be decreased by hypothalamic damage suggests that further comparative studie...

Hypothyroidism increases pancreatic thyrotropin-releasing hormone concentrations in adult rats.

Abstract: The effect of hypothyroidism on pancreatic TRH (P-TRH) and P-TRH-degrading activity (P-TRH-DA) was studied in adult rats. Hypothyroidism was induced in three groups during 4, 6, or 9 weeks by propylthiouracil (PTU) in drinking water and a low iodine diet (LID). Another group received PTU-LID for 6 weeks, followed by 5 weeks on a normal diet to restore euthyroidism. A possible toxic effect of PTU per se was eliminated by treating one control group with PTU and T3. P-TRH and TRH-DA were measured by specific RIA. In the hypothyroid groups, P-TRH concentrations (mean +/- SEM) were increased 10-fold (6.95 +/- 2.09; 5.51 +/- 1.3; 9.79 +/- 3.3 pg/(mg X 100 g BW), respectively, with a control value of 0.55 +/- 0.39, P less than 0.01). This increase was reversible, as shown by the group on PTU-LID followed by a normal diet (0.58 +/- 0.39, NS). P-TRH-DA present in the control group was decreased after 4 weeks of PTU-LID treatment and totally abolished after 6 and 9 weeks of PTU-LID treatment. In conclusion, these results suggest that thyroid status modulates P-TRH concentrations. This effect may be due to the disappearance of the TRH-DA in response to hypothyroidism. P-TRH stores may be regulated by the enzyme(s) involved in P-TRH-DA.

Thyroid function and reversal by antidepressant drugs of depressive-like behavior (escape deficits) in rats.

Abstract: Several investigations have suggested that a special relationship exists between thyroid function and affective disorders and/or therapeutic response to antidepressants. The present study shows that the reversal by clomipramine, desipramine, imipramine and nialamide of depressive-like behavior in rats (escape deficits produced by previous exposure to uncontrollable stress) was markedly attenuated in hypothyroid rats (propylthiouracil, 0.05% in the drinking water). Conversely, the effect of these same antidepressants was significantly hastened in euthyroid rats given daily triiodothyronine. This supports the notion of intricate thyroid/CNS interactions in the mechanisms of action of antidepressant drugs.