Propylthiouracil

About: Propylthiouracil is a research topic. Over the lifetime, 2181 publications have been published within this topic receiving 46996 citations. The topic is also known as: Thyreostat® & 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone.

Antithyroid effects of 3-amino-1,2,4-triazole.

Abstract: SummaryThe effects of 3-amino-1,2,-4-triazole (ATZ) on weight, content of iodine, and histology of the thyroid in rats were determined and compared to the effects of propylthiouracil (PTU), and KCIO4. In an 83-day period of treatment, ATZ and PTU produced goiters of comparable size. The KCIO4 treatment resulted in slightly greater depletion of iodine in the thyroid, smaller goiters, and less thyroxine depletion of the thyroid. The effect of ATZ treatment on intrathyroid metabolism of iodine in rats was studied and compared to similar studies in rats without treatment. In the ATZ-treated group, there was a progressive decrease in T3 and T4 and a slight increase in the proportion of MIT. The biologic half-life of 131I in the thyroid of the control and treated groups was 4.9 and 1.3 days, respectively. These findings are similar to those found previously for PTU and show that ATZ, like PTU, not only interferes with organification of iodine but also inhibits the coupling of iodotyrosines to form iodothyronines.

Effects of hyper- and hypothyroidism on the basal levels of angiotensin I and kinetic parameters of renin-angiotensin system in male rats.

Abstract: The basal levels of angiotensin I and kinetic parameters of renin-angiotensin system were studied under control, hyper- and hypothyroidism conditions. The serum levels of triiodothyronine (T3) and thyroxine (T4) and plasma angiotensin II have been measured radioimmunoassay. Hyperthyroidism was induced by 5.5 micrograms/200 g of T3 or 100 micrograms/200 g of T4 administration for 12 days, and hypothyroidism by propylthiouracil (PTU) administration of 1 mg/200 g for 12 days. Basal levels of angiotensin I and plasma renin activity (PRA) increased after T3 injection, were not altered by T4 and decreased after PTU administration. T3 and T4 induced an increase in plasma renin concentration (PRC), while PTU induced a decrease in PRC. Plasma renin substrate (PRS) decreased in hyperthyroid rats and was unchanged by experimentally induced hypothyroidism. A good correlation between T3 serum levels and PRA was found, but there was no such correlation between T4 serum levels and PRA.

Observations on the fine structure of propylthiouracil‐induced “brown degeneration” in the zona reticularis of mouse adrenal cortex

Abstract: Propylthiouracil (6-propyl-2-thiouracil), an anti-thyroid agent, was fed to mice in a concentration equal to 0.1% of their diet for periods of 10 and 15 weeks. The cells of the inner zone of the adrenal cortex were examined with the electron microscope. In animals receiving propylthiouracil for ten weeks mitochondria were altered and the smooth endoplasmic reticulum (SER) showed a marked focal proliferation. In contrast to control animals rough endoplasmic reticulum was abundant and was frequently associated with the hyperplastic SER. After 15 weeks these alterations were no longer present but had been replaced by a spectrum of "brown degeneration." The less affected cells were characterized by increased numbers of liposomes and lysosomes and the more affected cells by liposomal and mitochondrial degeneration. These observations emphasize that "brown degeneration" is a true degenerative process and not a spontaneous proliferation of ceroid pigment. It is suggested that the changes described may be directly related to an alteration in cholesterol metabolism.