Propylthiouracil

About: Propylthiouracil is a research topic. Over the lifetime, 2181 publications have been published within this topic receiving 46996 citations. The topic is also known as: Thyreostat® & 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone.

Changes in pituitary and thyroid function with increasing age in young male rats.

Abstract: As the age of young adult male rats increased from 30 to 150 days, the serum thyroxine (T4) decreased by 50% and the serum thyroid-stimulating hormone (TSH) increased by 250%. There was no change in the serum triiodothyronine (T3). The increment in serum TSH after injection of thyrotropin-releasing hormone (TRH) was not significantly different at any of the ages studied, but the old animals had significantly lower increments in serum T4 and T3 after subcutaneous administration of bovine TSH. Despite a higher basal serum TSH, the older rats had a lesser increase in serum TSH after thyroidectomy or propylthiouracil. Thus, 1) there is a progressive decline in intrinsic thyroid function between 30 and 150 days of age in male rats, and 2) pituitary TSH response to fall in serum concentration of thyroid hormones is also decreased with age.

Effect of orally administered propylthiouracil in pregnant and lactating rats on isolated aorta contractility of their adult male offspring.

Abstract: Summary Background: The effect of propylthiouracil (PTU) administration to pregnant and lactating rats on isolated aorta contractility of their adult offspring was investigated. Material/Methods: Three groups of female rats were selected; in the fetal group (FG), PTU was added to their drinking water during gestation; in the neonatal group (NG), PTU was added to the mothers’ drinking water for 25 days after delivery; untreated rats were controls (CG). Thyroid hormone concentrations were measured in the sera of the mothers and their adult offspring. Aortic contractility of the offspring was measured with an isometric transducer in the presence of different concentrations of potassium chloride (KCl) and phenylephrine. Results: The mothers were hypothyroid at the time of PTU cessation. Thyroid hormone levels in offspring were not signifi cantly different from those of controls except for TSH, which was signifi cantly (p<0.05) higher in the FG offspring. Recorded tension in FG offspring with 5, 10, 20, 40, and 60 mmol/l KCl were 0.21±0.02, 0.75±0.07, 1.07±0.07, 1.38±0.08, and 1.5±0.09 g/mm2 , respectively, signifi cantly (p<0.05) lower than the control values (0.43±0.05, 1.19±0.17, 1.76±0.23, 2.06±0.22, 2.5±0.09). Aortic contractility with 10 –8

Hyperthyroidism during pregnancy treated with propylthiouracil. The significance of maternal and foetal parameters.

Abstract: Hyperthyroidism during pregnancy may be dangerous to the infant. The major risks are prematurity and neonatal thyrotoxicosis. The latter may be due to placental transfer of thyroid stimulating immunoglobulins from mother to fetus. Of two siblings of a previously thyrotoxic mother the first had marked symptoms of neonatal thyrotoxicosis after a pregnancy where no antithyroid treatment was given. The second child had only minimal thyrotoxic symptoms but almost as high levels of thyroid hormones as the first. During the second pregnancy propylthiouracil was given to the mother from 26 weeks' gestation, because of increased fetal movements and fetal tachycardia. Fetal movements and fetal heart rate were considered to be most valuable indicators of thyroid function in the fetus. Intense control is necessary from the beginning of the second trimester.