Topic
Propylthiouracil
About: Propylthiouracil is a research topic. Over the lifetime, 2181 publications have been published within this topic receiving 46996 citations. The topic is also known as: Thyreostat® & 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone.
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TL;DR: Time-course studies demonstrated a slow decline in serum calcium levels over a 10 week period but a very rapid normalization of serum calcium (within 1 h) after replacement therapy with L-tri-iodothyronine, illustrating the considerable influence that thyroid hormones exert on calcium metabolism.
Abstract: Serum calcium was measured under different circumstances of thyroid dysfunction in male Sprague-Dawley and female Wistar rats. After induction of hypothyroidism with 131I and propylthiouracil, serum calcium fell from a control value of 2.43 +/- 0.08 mmol/l to 2.07 +/- 0.08 mmol/l (P less than 0.01). Thyroid hormone replacement therapy in hypothyroid rats caused a return of serum calcium to control values (2.09 +/- 0.04 mmol/l to 2.41 +/- 0.02 mmol/l, P less than 0.01). Treatment of normal rats with thyroid hormones caused elevation of serum calcium to 2.59 +/- 0.04 mmol/l compared with a control value of 2.44 +/- 0.02 mmol/l (P less than 0.01). Time-course studies demonstrated a slow decline in serum calcium levels over a 10 week period during induction of hypothyroidism with propylthiouracil alone but a very rapid normalization of serum calcium (within 1 h) after replacement therapy with L-tri-iodothyronine. These data illustrate the considerable influence that thyroid hormones exert on calcium metabolism and demonstrate for the first time consistent changes in serum calcium in the rat with hypo- and hyper-thyroidism.
13 citations
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13 citations
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TL;DR: A 71‐year‐old man with acrodermatitis continua of Hallopeau was treated successfully with a combination of oral propylthiouracil and methotrexate, and presented with a life‐threatening methicillin‐resistant Staphylococcus aureus pneumonia.
Abstract: A 71-year-old man with acrodermatitis continua of Hallopeau was treated successfully with a combination of oral propylthiouracil and methotrexate. After 14 weeks, he developed acute pancytopenia, an uncommon idiosyncratic side-effect of propylthiouracil, and presented with a life-threatening methicillin-resistant Staphylococcus aureus pneumonia. This illustrates the potential value and associated risks of propylthiouracil in the management of this difficult condition.
13 citations
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TL;DR: It is concluded that hypothyroidism alters IGF-I expression in the developing brain, and it is speculated that IGF-i plays a role in mediating some thyroid hormone actions during brain development.
13 citations
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TL;DR: Treatment of rats with propylthiouracil for one to two weeks caused an increase in glutathione S-transferase (GST) activity of the liver cytosol, but not of the particulate fraction, and enzyme activity towards chlorodinitrobenzene was the highest.
Abstract: Treatment of rats with propylthiouracil for one to two weeks caused an increase in glutathione S-transferase (GST) activity of the liver cytosol, but not of the particulate fraction. Increased GST activity was reversed two weeks after discontinuing PTU administration. Activation of the enzyme was inversely proportional to the decrease in leukocytes. Repeated administration of PTU increased the Vmax of the enzyme without affecting the Km value for the substrate 1-chloro-2,4-dinitrobenzene, whereas both the Km and Vmax for glutathione (GSH) were increased by PTU treatment. GSH content and GSH peroxidase activity were not affected by PTU, but this resulted in an increase in glucose 6-phosphate dehydrogenase activity. PTU treatment caused increase in GST activity using 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene, p-nitrobenzyl chloride, and benzalacetone as substrates; enzyme activity towards chlorodinitrobenzene was the highest.
12 citations