Propylthiouracil

About: Propylthiouracil is a research topic. Over the lifetime, 2181 publications have been published within this topic receiving 46996 citations. The topic is also known as: Thyreostat® & 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone.

Ethanol has thyrotropin-like activity in cultured porcine thyroid follicles

Abstract: We describe TSH-like activity of ethanol for thyroid hormone formation in the physiological culture system. Porcine thyroid follicles were preincubated with 0-100 mM (0-0.58%) ethanol in the presence of 0-1280 microU/ml bovine TSH for 24 h; these follicles were then incubated with the mixture of Na125I and NaI to measure iodide uptake, iodine organification, and de novo thyroid hormone formation. Ethanol stimulated iodide uptake in a dose-response manner in TSH-free medium. Ethanol augmented the effect of TSH on iodide uptake, iodide organification, and thyroid hormone formation in the presence of 20-80 microU/ml TSH. When TSH concentration was 320 microU/ml or greater, ethanol no longer stimulated iodide uptake and thyroid hormone formation. Ethanol mediated iodide uptake and iodine organification were inhibited by potassium perchlorate and propylthiouracil respectively. The effect of ethanol on the thyroid follicle was reversible 24 h after removal of ethanol from the medium. The mechanism of TSH-like a...

Antenatal management of recurrent fetal goitrous hyperthyroidism associated with fetal cardiac failure in a pregnant woman with persistent high levels of thyroid-stimulating hormone receptor antibody after ablative therapy

Abstract: High titer of maternal thyroid-stimulating hormone receptor antibody (TRAb) in patients with Graves' disease could cause fetal hyperthyroidism during pregnancy. Clinical features of fetal hyperthyroidism include tachycardia, goiter, growth restriction, advanced bone maturation, cardiomegaly, and fetal death. The recognition and treatment of fetal hyperthyroidism are believed to be important to optimize growth and intellectual development in affected fetuses. We herein report a case of fetal treatment in two successive siblings showing in utero hyperthyroid status in a woman with a history of ablative treatment for Graves' disease. The fetuses were considered in hyperthyroid status based on high levels of maternal TRAb, a goiter, and persistent tachycardia. In particular, cardiac failure was observed in the second fetus. With intrauterine treatment using potassium iodine and propylthiouracil, fetal cardiac function improved. A high level of TRAb was detected in the both neonates. To the best of our knowledge, this is the first report on the changes of fetal cardiac function in response to fetal treatment in two siblings showing in utero hyperthyroid status. This case report illustrates the impact of prenatal medication via the maternal circulation for fetal hyperthyroidism and cardiac failure.

Kinetics of the human thyroid trap: effects of iodide, thyrotropin, and propylthiouracil.

Abstract: Effects on the thyroidal pertechnetate trap of iodide, thyrotropin (TSH), and pro pylthiouracil (PTU), compared with duplicated control studies, were assessed in nOrmal subjects using i.v. [Tc@@m] pertechnetate, a multicrystal scintillation camera, and a compartmental model. Sodium iodide (1 g), administered orally on two occasions, 2 wk apart, caused an early drop in plasma clearance into the follicular cell (p < 0.05), with later return to normal clearance 1 wk after the second Na! dose. In this later study, exit from the colloid was elevated (p < 0.01). Plasma equivalent volume ofthe “colloid” compart ment was reduced in both postiodine studies (p < 0.05). Thyrotropin, 10 units intramuscularly, was followed by no significant changes in trap parameters at 2 hr. At 24 hr, plasma clearance had doubled (p < 0.05), and the plasma equivalent “colloid” volume had tripled (p < 0.01). Propylthiouracil was given as a single 1 g dose 1 hr before a trapping study, followed by 200 mg PTU every 8 hrfor 1 wk. The first dose resulted in apparent reduction in all of the rate constants for transport across the basal and apical thyroidfollicular cell membranes; these rates returned toward control levels after 1 wk. The plasma equiv dent ‘ ‘follicularcell”volume was reduced to 66% of control levels (p < 0.025) after 1 wk PTU. These effects must be taken into account in the interpretation ofstudies of the trap based on flU pretreatment to inhibit organification.