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Propylthiouracil

About: Propylthiouracil is a research topic. Over the lifetime, 2181 publications have been published within this topic receiving 46996 citations. The topic is also known as: Thyreostat® & 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone.


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Journal ArticleDOI
TL;DR: Data are consistent with a potential role of thyroid hormone in the postnatal increase in Na+/H+ antiporter activity.

70 citations

Journal ArticleDOI
TL;DR: There is a critical period during the first 8 days of postnatal life when thyroid hormone levels must be adequate in order that spinal cord activity of this enzyme develops normally, it is concluded.
Abstract: The effects of triiodothyronine administration and of hypothyroidism on the rapidly developing enzymes UDP galactose: sphingosine galactosyltransferase and 2′:3′-nucleotide 3′-phosphohydrolase associated with central nervous system myelination were investigated. The activity of these enzymes in the spinal cords of young rats injected daily with triiodothyronine up to sacrifice on day 5 was significantly increased over control animals. In normal animals, circulating plasma thyroxine increased gradually from the second postnatal day to a maximum value at days 15–17. Rats, born of mothers treated with n-propylthiouracil from the thirteenth day of pregnancy, did not exhibit the increase in plasma thyroxine. Determination of the specific activity of these enzymes in central nervous tissue of such hypothyroid rats at day 12 showed a significant reduction compared with normal animals. Intraperitoneal injection of the hypothyroid rats with triiodothyronine on day 8 resulted in a partial restoration of the activity of the enzymes in brain and of 2′:3′-nucleotide 3′-phosphohydrolase in spinal cord when assayed on day 12. Restoration of UDPgalactose: sphingosine galactosyltransferase activity did not occur in the spinal cord of such animals. However, when hypothyroid rats were injected with triiodothyronine on days 1, 4, and 7, the psychosine-synthesising activity in their spinal cords on day 8 was restored to that of normal animals. This suggests that there is a critical period during the first 8 days of postnatal life when thyroid hormone levels must be adequate in order that spinal cord activity of this enzyme develops normally. It is concluded that the flux in circulating thyroid hormone is a factor in the normal development of these enzymes.

70 citations

Journal ArticleDOI
TL;DR: The findings suggest a relationship between the hypothyroid status of lactating cows and the rearrangement of organ-specific 5'-deiodinase activity related to the maintenance of the udder's function.

69 citations

Journal ArticleDOI
B. Marchant1, W. D. Alexander1, J.H. Lazarus1, Jean F. H. Lees1, D. H. Clark1 
TL;DR: In man both 35S-radioactivity and the parent drug accumulated in the normal thyroid after administration of methimazole and propylthiouracil and in six thyroid tumors little or no accumulation of the antithyroid drug was found.
Abstract: Accumulation of 35S-radioactivity by the thyroid gland was found after administration of equimolar doses of 35S-labelled thiouracil, methylthiouracil, propyl thiouracil, methimazole and carbimazole to rats. Thin-layer chromatography showed an accumulation of the parent drug in the case of methimazole, propylthiouracil, methylthiouracil and thiouracil. When carbimazole was given, an accumulation of methimazole was demonstrated in the thyroid. Propylthiouracil administration produced the largest amount of drug in the thyroid and thiouracil the least. In man both 35S-radioactivity and the parent drug accumulated in the normal thyroid after administration of methimazole and propylthiouracil. When carbimazole was given, methimazole accumulated in the thyroid. In six thyroid tumors little or no accumulation of the antithyroid drug was found.

68 citations

Journal ArticleDOI
TL;DR: Many investigators have reported that the thyroids are enlarged in offspring from mothers treated with antithyroid agents during pregnancy, and D’Angelo and Gordon (1950) have since shown that administration of propylthiouracil is followed by increased concentration of TSH in the serum.
Abstract: Many investigators have reported that the thyroids are enlarged in offspring from mothers treated with antithyroid agents during pregnancy (mouse—Kaufman, Hurst and Turner, 1948; rat—Hughes, 1944; Goldsmith, Gordon and Charipper, 1945; guinea pig—Albrieux, Estefan and Gonzalez, 1946; Webster and Young, 1948; goat—Schultze and Turner, 1945; man—Davis and Forbes, 1945; Eaton, 1945). This has been taken as evidence for the placental passage of an antithyroid effect The placental passage of the antithyroid effect could occur in one or more of three ways (Goldsmith, Gordon and Charipper, 1945). Thyrotrophin (TSH) from the maternal pituitary might cross the placenta to affect the fetal thyroid. D’Angelo and Gordon (1950) have since shown that administration of propylthiouracil is followed by increased concentration of TSH in the serum. Second, the goitrogen might pass the placenta to inhibit thyroid hormone production in the fetus. This would lead to stimulation of the fetal thyroid by TSH secreted by its own p...

68 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202342
202276
202138
202032
201934
201829