Topic
Propylthiouracil
About: Propylthiouracil is a research topic. Over the lifetime, 2181 publications have been published within this topic receiving 46996 citations. The topic is also known as: Thyreostat® & 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone.
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TL;DR: The results obtained showed that these goitrogens depress extrathyroidal deiodination of l-thyroxine to about half its normal amount; subsequently a larger fraction of the hormone is excreted via the fecal route.
Abstract: Thyroidcctomized, l-thyroxine maintained rats were equilibrated isotopically with exogenous I131 labeled l-thyroxine and later treated with propylthiouracil, methylthiouracil or thiouracil. The ensuing alterations in the distribution of radioactive compounds were determined. The results obtained showed that these goitrogens depress extrathyroidal deiodination of l-thyroxine to about half its normal amount; subsequently a larger fraction of the hormone is excreted via the fecal route. Concentration of labeled compounds in the peripheral tissues is not greatly influenced, whereas the level of circulating hormone is usualty increased above normal values. It is concluded that these “antithyroid” drugs have also a very rapid and intense action on the peripheral metabolism of l-thyroxine.
65 citations
TL;DR: Antithyroid thionamides inhibit lactoperoxidase which contributes to the antibacterial activities of a number of mammalian exocrine gland secretions that protect a variety of mucosal surfaces and affect gene expression and modulate the functions of some cell types.
65 citations
TL;DR: It is suggested that rats were more sensitive to the antithyroid effects of PTU and SMM than monkeys, and that inhibition of thyroid peroxidase may play an important role in species difference in the antithsyroid effect of the two drugs.
64 citations
TL;DR: The sites of transferrin synthesis and the factors affecting synthesis were investigated in the rat by measuring the incorporation of 14C-leucine into transferrin, albumin, and γG-globulin precipitated with specific antisera as discussed by the authors.
64 citations
TL;DR: It appears from this study that the close metabolic relationship between the liver/kidney and the thyroid should be taken into consideration when the findings of chronic toxicology and carcinogenicity studies are interpreted.
64 citations