Topic
Protoporphyrin IX
About: Protoporphyrin IX is a research topic. Over the lifetime, 2250 publications have been published within this topic receiving 65544 citations. The topic is also known as: PpIX.
Papers published on a yearly basis
Papers
More filters
TL;DR: Porphobilinogen (1), [2H]-labelled in the propionic residue, is synthesised by a short route and is used to establish that both vinyl groups of protoporphyrin-IX are biosynthesised by overall antiperiplanar elimination of a proton and carbon dioxide.
Abstract: Porphobilinogen (1), [2H]-labelled in the propionic residue, is synthesised by a short route and is used to establish that both vinyl groups of protoporphyrin-IX are biosynthesised by overall antiperiplanar elimination of a proton and carbon dioxide.
30 citations
TL;DR: Results indicated that the ultrasonically-induced cell killing effect could be enhanced by PpIX, and that the mitochondrial pathway might be involved in the cell damage process.
Abstract: Sonodynamic therapy (SDT) is a potential cancer therapy based on the synergistic interactions of ultrasound and certain chemical compounds (sono-sensitizers). It has become evident that the direct sonochemical and subsequent redox reactions induced by SDT treatment can lead to apoptotic cell death. However, the detailed mechanisms are not well understood. This study sought to identify the cytotoxic effects of ultrasound-activated protoporphyrin IX (PpIX) on Hepatoma-22 cells (H22). The fluorescence microscope was used to detect the generation of mitochondrial reactive oxygen species (ROS), mitochondrial swelling and release of mitochondrial protein cytochrome c. Several distinct sonochemical effects were found after SDT treatment, including changes of cell viability (decreased to 82.6% in SDT-treated group), generation of mitochondrial ROS, mitochondrial swelling and release of cytochrome c (19.16% in SDT-treated group). These results indicated that the ultrasonically-induced cell killing effect could be enhanced by PpIX, and that the mitochondrial pathway might be involved in the cell damage process.
30 citations
TL;DR: Protoporphyrin IX inhibition of nitric oxide synthase is a multisite, positively cooperative inhibition that exhibits a Hill coefficient of 2.3 for the iNOS isoform and may contribute to the pathophysiology of these conditions.
30 citations
TL;DR: It is proposed that iron regulatory protein activation could serve as a marker for developing photodynamic therapy protocols because it identifies cells and tissues with a propensity to accumulate PPIX and it is therefore likely to predict the effectiveness of such therapies.
30 citations
TL;DR: expression of the green fluorescent protein (EGFP) transgenes driven by various ferrochelatase promoter fragments into a single locus in mouse embryonic stem cells was introduced to investigate the role of these elements during erythropoiesis and the effect of an A-to-G polymorphism identified in the promoters of patients with protoporphyria.
30 citations