Topic
Protoporphyrin IX
About: Protoporphyrin IX is a research topic. Over the lifetime, 2250 publications have been published within this topic receiving 65544 citations. The topic is also known as: PpIX.
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TL;DR: This study shows that PVP-hypericin appears to have great potential as a photodynamic agent against non-muscle-invasive bladder cancers after intravesical administration, with a limited risk of affecting the deeper layers of the bladder.
Abstract: Purpose
In this preclinical study, we examined the biodistribution of hypericin formulated as its water-soluble PVP-hypericin complex in the different layers (urothelium, submucosa, muscle) of a normal rat bladder and a rat bladder bearing a malignant urothelium composed of syngeneic AY-27 tumor cells. The results were compared with the biodistribution of hexaminolevulinate (HAL)-induced protoporphyrin IX (PpIX).
25 citations
TL;DR: In this article, a review of the biosynthesis of chlorophylls and bacteriochlorophyll from protoporphyrin IX with 235 references is presented, and the literature on the enzymes magnesium chelatase, S-adenosyl-L-methionine:magnesium protoprorin IX O-methyltransferase, magnesium-protoporphyrins IX monomethyl ester oxidative cyclase, protochlorophyllide oxidoreductase, chlorophyLLide 8-vinyl reductase, and chlorophy
Abstract: Covering: 1989 to 2002. Previous review: Nat. Prod. Rep., 1989, 6, 171
A review of the biosynthesis of chlorophylls and bacteriochlorophylls from protoporphyrin IX with 235 references. The literature on the enzymes magnesium chelatase, S-adenosyl-L-methionine:magnesium protoporphyrin IX O-methyltransferase, magnesium-protoporphyrin IX monomethyl ester oxidative cyclase, protochlorophyllide oxidoreductase, chlorophyll synthase, bacteriochlorophyll synthase, protochlorophyllide 8-vinyl reductase and chlorophyll a oxidase from 1989 is discussed.
25 citations
TL;DR: The crystal structure of the MnIII form of ovine prostaglandin H2 synthase-1 is described and the out-of-plane displacement of the manganese ion with respect to the porphyrin is greater than that of the iron by approximately 0.2 A, which may help to explain the altered catalytic properties of theManganese enzyme.
Abstract: Prostaglandin H2 synthase (EC 1.14.99.1) is a clinically important drug target that catalyzes two key steps in the biosynthesis of the eicosanoid hormones. The enzyme contains spatially distinct cyclooxygenase and peroxidase active sites, both of which require a heme cofactor. Substitution of ferric heme by MnIII protoporphyrin IX greatly diminishes the peroxidase activity, but has little effect on the cyclooxygenase activity. Here, the 2.0 A resolution crystal structure of the MnIII form of ovine prostaglandin H2 synthase-1 is described (R = 21.8%, Rfree = 23.7%). Substitution of MnIII for FeIII causes no structural perturbations in the protein. However, the out-of-plane displacement of the manganese ion with respect to the porphyrin is greater than that of the iron by approximately 0.2 A. This perturbation may help to explain the altered catalytic properties of the manganese enzyme.
25 citations
TL;DR: In this paper, the 1,3-Dipolar cycloaddition mechanism of the formation of 1′-pyrazolinyl derivatives is discussed, and a mixture of mono-and di-substituted pyrazolin analogs are isolated as individual products.
25 citations
TL;DR: The amount of ZPP in Parma ham was larger than that of heme, and ZPP accounted for 60-70% of all porphyrins.
25 citations