Topic
Protoporphyrin IX
About: Protoporphyrin IX is a research topic. Over the lifetime, 2250 publications have been published within this topic receiving 65544 citations. The topic is also known as: PpIX.
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TL;DR: Developing chloroplasts were isolated from greening Cucumis cotyledons in a co-factor-enriched medium and were incubated in the dark with 14C-labeled and unlabeled protoporphyrin IX and it was shown that protoborphyr in IX, a postulated intermediate of the chlorophyll biosynthetic pathway, was convertible into protochlorophyllide.
24 citations
TL;DR: Results showed that PpIX-PA exerted its maximum effects without activating resistance pathways and appears to be a good candidate for prostate cancer PDT treatment.
24 citations
TL;DR: Effet isotopique "solvant" observe lors de la photooxydation de la protoporphyrine IX en microemulsion, formation de produits a fonction aldehyde et alcool.
Abstract: Effet isotopique «solvant» observe lors de la photooxydation de la protoporphyrine IX en microemulsion, formation de produits a fonction aldehyde et alcool. Mecanisme
24 citations
TL;DR: The results suggest that the coordinate gene regulation pattern of HBP23 and HO-1 plays a physiological role against oxidative stress.
24 citations
TL;DR: Chronic exposure to low glucose induces photodynamic therapy resistance despite increased intracellular concentrations of protoporphyrin IX and may reflect cellular adaptation to chronic glucose deprivation.
Abstract: Photodynamic therapy is a cancer treatment based on the interaction of light, oxygen and a photosensitiser Protoporphyrin IX is an endogenous photosensitiser derived from the pro-drug aminolaevulinic acid Tumours contain areas of hypoxia and hypoglycaemia Tumour cells adapt to these conditions by stress protein induction which may induce resistance to cancer therapies The effect of chronic hypoglycaemia on sensitivity to aminolaevulinic acid-induced photodynamic therapy in vitro was studied in MCF-7, human breast cancer cells Following chronic exposure to 0, 1 or 25 mM, glucose, cells were treated with aminolaevulinic acid and the generation of intracellular protoporphyrin IX measured by spectrofluorimetry Aminolaevulinic acid-induced photodynamic therapy sensitivity was compared between cells following chronic exposure to 0, 1 or 25 mM glucose Percentage cell survival was determined by clonogenic assay Cells cultured in low glucose generated higher levels of protoporphyrin IX compared to standard glucose medium (0 mM glucose: 088 x 10(-5) ng cell(-1), 1 mM: 086 x 10(-5) ng cell(-1), 25 mM: 060 5x 10(-5) ng cell(-1), P<005) However, photodynamic therapy sensitivity was reduced in glucose deprived cells (0 mM glucose: 61% survival, 1 mM: 805% and 25 mM: 396%, P<005) Chronic exposure to low glucose induces photodynamic therapy resistance despite increased intracellular concentrations of protoporphyrin IX and may reflect cellular adaptation to chronic glucose deprivation
24 citations