Topic
Protoporphyrin IX
About: Protoporphyrin IX is a research topic. Over the lifetime, 2250 publications have been published within this topic receiving 65544 citations. The topic is also known as: PpIX.
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59 citations
TL;DR: The results show that skin 5-ALA penetration and PpIX accumulation, important factors for the success of topical 5- ALA-PDT in skin cancer, are optimized by GMO/propylene glycol formulations.
59 citations
TL;DR: The atomic details and structural rearrangements presented herein significantly advance the understanding of the substrate binding mode of ferrochelatase and reveal new conformational changes in a structurally conserved pi-helix that is predicted to have a central role in product release.
59 citations
TL;DR: Different cell lines were given photodynamic treatment with 5-aminolaevulinic acid (ALA) and light and the iron chelator 1,2-diethyl-3-hydroxypyridin-4-one (CP94) was used, and the porphyrin species produced was spectrofluorimetrically identified as protoporphyr in IX.
Abstract: Different cell lines were given photodynamic treatment with 5-aminolaevulinic acid (ALA) and light. In addition, the iron chelator 1,2-diethyl-3-hydroxypyridin-4-one (CP94) was used. The porphyrin species produced was spectrofluorimetrically identified as protoporphyrin IX. All the cell lines responded to treatment, including a multidrug resistance gene expressing bladder cancer line and, to a lesser degree, cells derived from untransformed human skin fibroblasts. CP94 enhanced both porphyrin fluorescence, total porphyrin content and photosensitivity of the cells. CCD fluorescence microscopy showed a granular extranuclear porphyrin fluorescence distribution for all the cell lines involved, but the untransformed cells showed a distribution pattern different from the ones seen in the other cells.
59 citations
TL;DR: The data presented demonstrate that human CPO contains no metal center, that it is not stimulated in vitro by iron or copper, and that addition of these metals to cultures expressing the protein has no effect.
59 citations