Showing papers on "Protoporphyrins published in 2002"
TL;DR: It was shown that prolongation of this group caused an increase in the lipophilicity and the liposome-binding constant, and this effect is more pronounced for the proto- than for the hematoporphyrin series.
Abstract: We tested correlations between lipophilicity parameters and the partitioning of sensitizers into membranes. For this purpose we investigated 17 porphyrins and two chlorins having various chemical structures. Some of these compounds possess an amphiphilic structure (including hematoporphyrin, deuteroporphyrin, mesoporphyrin, chlorin e6 and more). The others are very symmetrical sensitizers [meso-tetra(N-methyl-4-pyridyl)porphyrin, tetrabenzoporphyrin, coproporphyrin I dihydrochloride (CP), meso-tetra(4-carboxyphenyl)porphyrin (TCP) and meso-tetra(m-hydroxyphenyl)chlorin]. Our investigation also included two series of hematoporphyrins and protoporphyrins with varying lengths of alkylcarboxylate side groups. The partitioning of these compounds between the bulk aqueous phase and liposomes was studied by fluorescence methods, and a liposome-binding constant, Kb, was obtained. It was found that CP and TCP do not incorporate into the lipid phase at pH 7.3. An n-octanol–water partition coefficient (log P...
105 citations
TL;DR: In this paper, a new approach to synthesize protoporphyrins III (2′ ) and XIII (3′ ) has been developed based on a single set of starting materials, namely, 2,4-dimethyl-3-(2-chloroethyl)carbethoxypyrrole ( 4 ) and 3,3′-di(2-methoxycarbonylethyl)-4,4′-dimethyldipyrromethane-5,5′-dicarboxylic acid ( 5 ) for both targets.
4 citations
Patent•
10 Oct 2002
TL;DR: In this article, a spectral-fluorescence assay of an extract of porphyrin fraction of venous blood erythrocytes was used to detect the concentration of copro- and protoporphyrins.
Abstract: medicine, obstetrics. SUBSTANCE: method deals with periodic blood testing, that is: spectral- fluorescent assay of an extract of porphyrin fraction of venous blood erythrocytes. Moreover, one should detect the concentration of copro- and protoporphyrins and at the ratio value of protoporphyrins concentration to coproporphyrins concentration being under 10 gestosis is diagnosed. EFFECT: increased information value and increased number of methods for early diagnostics of gestosis. 1 ex
1 citations