Topic
Protoporphyrins
About: Protoporphyrins is a research topic. Over the lifetime, 145 publications have been published within this topic receiving 3486 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: A method for achieving and maintaining moderate levels of nutritional iron deficiency in the male albino rat was described, based upon the age of the animals when iron-deficient conditions were introduced.
Abstract: A method for achieving and maintaining moderate levels of nutritional iron deficiency in the male albino rat is described. Hemoglobin concentrations and protoporphyrin/heme ratios were the parameters used to assess iron status. The method was based upon the age of the animals when iron-deficient conditions were introduced.
1 citations
TL;DR: In this article, the macrocycle of porphyrins 1 and 3 was shown to be planar while nonplanar saddle conformations were obtained for porphrin 2 and 4, and the exocyclic phenyl group adopts a non-coplanar disposition relative to the plane of the macrocycler.
1 citations
Journal Article•
1 citations
TL;DR: A low-energy collision-activated dissociation (CAD) study of a series of aliphatic amines revealed that at collision energies above 200 eV, charge-site-initiated fragmentation occurs, and this method was used to identify the alkyl group of a biologically derived N-alkyl protoporphyrin.
Abstract: A low-energy (5-450 eV) collision-activated dissociation (CAD) study of a series of aliphatic amines revealed that at collision energies above 200 eV, charge-site-initiated fragmentation occurs. The resulting fragment ions can be utilized in the characterization of alkyl substituents of di- and trisubstituted aliphatic amines. In the presence of Cu2+ and a suitable nucleophile, such as n-dodecylamine, N-alkyl protoporphyrins dealkylate to afford copper protoporphyrin and an alkyl-dodecylamine adduct. A CAD study of a number of alkyl-dodecylamine adducts derived from the copper-induced dealkylation of synthetic N-alkyl protoporphyrins, using charge-site-initiated fragment ions, showed that the alkyl group was trapped by the nucleophilic amine present. Subsequently this method was used to identify the alkyl group of a biologically derived N-alkyl protoporphyrin.
1 citations
Patent•
10 Sep 2006
TL;DR: In this paper, the amplitude of fluorescence of protoporphyrin IX was determined by using low-intensity laser radiation, wave length corresponds to one of the maximums of the proptoporphrin's absorption range and wave lengths corresponding to the maximum of the absorption range correspond to 337, 370, 405, 532, 632 nm.
Abstract: FIELD: medicine, diagnostics. ^ SUBSTANCE: due to spectrophotometry on should study body biological material to detect the concentration of porphyrin in tissues of biological material and compare it values against the standard. As biological material one should apply that part of the tissue at patient's body where spectrophotometric investigation should be carried out in vivo. Moreover, One should affect this part with low-intensity laser radiation, wave length corresponds to one of the maximums of protoporphyrins' absorption range. One should determine the amplitude of fluorescence radiation of this part. As a standard for comparison one should take the amplitude of fluorescence of protoporphyrin IX that models the concentration of protoporphyrin in blood erythrocytes ranged 100-1500 mcg/l and more. At equality of amplitudes it is necessary to establish concentration of proptoporphyrin IX in blood erythrocytes of biological tissue under testing. Moreover, wave lengths corresponding to maximums of absorption range of protoporphyrins correspond to 337, 370, 405, 532, 632 nm. The innovation enables to considerably simplify the investigation of values that indirectly characterize lead concentration in tissues and, thus, total degree lead intoxication in patients with the risk of lead intoxication. ^ EFFECT: higher efficiency of diagnostics. ^ 1 cl, 1 ex
1 citations