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Protoporphyrins

About: Protoporphyrins is a research topic. Over the lifetime, 145 publications have been published within this topic receiving 3486 citations.


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Book ChapterDOI
TL;DR: Evidence is provided that the isomeric composition of the N-ethyl protoporphyrin produced in vivo by treatment with 4-ethyl-DDC depends on the particular cytochrome P-450 which predominates at the time of treatment, suggesting a role for the apo-cytochrome in directing alkylation preferentially on to one of the pyrrole nitrogens.
Abstract: Substituted dihydropyridines, like DDC and its 4-ethyl analogue (4-ethyl-DDC)* give rise to N-alkylated porphyrins when given to rats and mice in vivo, by donating their intact 4-alkyl group to one of the pyrrole nitrogens of haem in hepatic cytochrome P-450 (De Matteis et al., 1981; Ortiz de Montellano et al., 1981; Tephly et al., 1981). Because of the asymmetrical arrangement of the two vinyl and propionate side chains in protoporphyrin IX, four structural isomers of N-monoalkylated protoporphyrins are possible, according to which of the four pyrrole nitrogens has been substituted. In a previous paper (De Matteis et al., 1983) we have provided evidence that the isomeric composition of the N-ethyl protoporphyrin produced in vivo by treatment with 4-ethyl-DDC depends on the particular cytochrome P-450 which predominates at the time of treatment, suggesting a role for the apo-cytochrome in directing alkylation preferentially on to one of the pyrrole nitrogens. In this present paper we wish to report additional findings in vivo which are compatible with this interpretation. Production of N-ethyl protoporphyrin is also found in vitro, when isolated microsomes are incubated with 4-ethyl-DDC in presence of NADPH and, although a change in isomeric profile is again found with microsomes containing different cytochrome P-450 enzymes, nevertheless the picture obtained with isolated membranes in vitro is different from that seen in the intact cells in vivo.
Journal ArticleDOI
TL;DR: In these studies, CO(III) protoporphyrin IX chloride obtained from Frontier Laboratories was used as a raw material for the studies on soluble guanylyl cyclase and the antihypertensive actions of heme oxygenase-1 induction in the kidney.
Abstract: We would like to thank Dr. Danziger1 for his interest in our work and his thoughtful commentary about the role of soluble guanylyl cyclase (sGC) in mediating the antihypertensive actions of heme oxygenase-1 (HO-1) induction in the kidney. In our studies, we used CO(III) protoporphyrin IX chloride obtained from Frontier …
Journal ArticleDOI
TL;DR: The results suggest that PROTO, FEP, or ZnPROTO could serve as a biological indicator of lead poisoning in ring teal ducks.
Abstract: This research determined the relationships between blood lead level and zinc protoporphyrin (ZnPROTO), protoporphyrin IX (PROTO), and free erythrocyte protoporphyrin (FEP) levels in a group of 18 ring teal ducks. Blood samples were drawn from two groups of ring teal ducks as part of the routine health maintenance program of the New York Zoological Park. One group of six teals had been exposed to what is believed to be lead-contaminated dust, while the second group of twelve teals was unexposed. Blood samples were analyzed for lead by flameless atomic absorption and for protoporphyrins by fluorescence. Blood lead level and log blood lead level had positive correlations with each of the protoporphyrins: the logarithmic correlations were better than the nonlogarithmic correlations, and PROTO correlated better than ZnPROTO. With one exception, PROTO levels were higher than ZnPROTO levels. The results suggest that PROTO, FEP, or ZnPROTO could serve as a biological indicator of lead poisoning in ring teal ducks.
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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20212
20191
20181
20173
20162
20152