Showing papers on "Psychotropic drug published in 1971"

DOET (2,5-dimethoxy-4-ethylamphetamine), a new psychotropic drug. Effects of varying doses in man.

Abstract: DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the ethyl homologue of DOM (2,5-dimethoxy-4-methylamphetamine), a psychotomimetic drug widely used by hippie populations and designated "STP." DOET was administered to normal male subjects in doses ranging from 0.75 to 4 mg and contrasted with effects of a water placebo. In all cases DOET produced subjective effects including a mild euphoria, a feeling of enhanced self-awareness, and a tendency to feel "anxious" at higher doses. Although there was some increase in subjective effects at higher doses, this was not marked. No hallucinogenic or psychotomimetic effects were observed at any dose. Thus, over a five-fold range of pharmacologically active dosage, the "enhanced awareness" produced by DOET was not associated with psychotomimetic or hallucinogenic actions. PSYCHEDELIC drugs embrace a large number of agents of widely different chemical classes but which produce notably similar profound subjective effects. 1 Nuances of subjective effects which may vary among drugs 2 have not been well quantified. Shulgin 3.4 has synthesized a large number of methoxylated amphetamines related to mescaline and amphetamine. One of these, DOM (2, 5-dimethoxy-4-methylamphetamine) (Fig 1), informally designated "STP," was psychotomimetic and hallucinogenic in doses larger than 5 mg, and was about 50 to 100

Psychotropic Drug Advertisements

Abstract: Excerpt To the editor: American pharmacists filled 225 million prescriptions for stimulants, sedatives, and tranquilizers in 1970 (The New York Times, March 14, 1971, p. 36). Some estimates indicat...

Histochemical effects of fluacizine on flavin dehydrogenase activity in the rat brain

Abstract: The effect of the new psychotropic drug fluacizine on the activity and distribution offlavin dehydrogenases was studied in the ra t brain by his tochemical methods. After a single injection, fluaeizine caused a moderate or slight decrease in activity of the enzymes in many brain s t ruc tu res . In a longte rm experiment, besides reducing enzyme activity, the drug also led to definite activation of the flavin dehydrogenases in some parts of the cortex and subcortex.

The behavioral effects of a new psychoactive drug (d-carbine) on a passive avoidance response and locomotion and its interaction with amphetamine.

Abstract: The relationship between amphetamine and a new psychotropic drug, carbidin (in comparison with imipramine and chlorpromazine) was studied on a test of activity and the passiv avoidance conditioned response.