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Psychotropic drug

About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.


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Journal ArticleDOI
TL;DR: The history of research on various neurohumors that control behavior appears to be very cyclical; each decade having a favorite chemical mediator implicated in behavioral control and in psychotropic drug action.

26 citations

Journal ArticleDOI
TL;DR: Amygdala volume loss is more pronounced in MDD with an intermediate degree of volume loss in BPD compared to HC, yet amygdala volume is associated with affective symptom expression in both disorders.

26 citations

Journal ArticleDOI
TL;DR: Prescription rates for antipsychotics are similar compared to other countries, and relatively low for antidepressants, anxiolytics, and hypnotics, which indicates that improvement of prescribing could provisionally best be targeted at resident-related factors.
Abstract: Objectives: To determine psychotropic drug prescription rates in nursing home residents with dementia and to identify associations with the so far understudied psychosocial non-resident-related factors.Method: A cross-sectional, observational, exploratory design as part of PROPER I (PRescription Optimization of Psychotropic drugs in Elderly nuRsing home patients with dementia). Participants were 559 nursing home residents with dementia, 25 physicians, and 112 nurses in the Netherlands. Psychotropic drug prescription, non-resident-related and known resident-related variables were measured to operationalize the themes of our previous qualitative analysis.Results: Fifty-six percent of residents were prescribed any psychotropic drug, 25% antipsychotics, 29% antidepressants, 15% anxiolytics, and 13% hypnotics, with large differences between the units. Multivariate multilevel regression analyses revealed that antipsychotic prescription was less likely with higher physicians’ availability (odds ratio 0.9...

26 citations

Journal ArticleDOI
TL;DR: It is hypothesized that electrocardiography features may distinguish SUDEP cases from living subjects with epilepsy, and the overall prevalence exceeded that of published community‐based cohorts.
Abstract: Sudden unexpected death in epilepsy (SUDEP) is the most common cause of epilepsy-related mortality We hypothesized that electrocardiography (ECG) features may distinguish SUDEP cases from living subjects with epilepsy Using a matched case-control design, we compared ECG studies of 12 consecutive cases of SUDEP over 10 years and 22 epilepsy controls matched for age, sex, epilepsy type (focal, generalized, or unknown/mixed type), concomitant antiepileptic, and psychotropic drug classes Conduction intervals and prevalence of abnormal ventricular conduction diagnosis (QRS ≥110 msec), abnormal ventricular conduction pattern (QRS <110 msec, morphology of incomplete right or left bundle branch block or intraventricular conduction delay), early repolarization, and features of inherited cardiac channelopathies were assessed Abnormal ventricular conduction diagnosis and pattern distinguished SUDEP cases from matched controls Abnormal ventricular conduction diagnosis was present in two cases and no controls Abnormal ventricular conduction pattern was more common in cases than controls (58% vs 18%, p = 004) Early repolarization was similarly prevalent in cases and controls, but the overall prevalence exceeded that of published community-based cohorts

26 citations

Journal ArticleDOI
TL;DR: It is unlikely that the political violence caused any marked increase in serious psychiatric illnesses but rather stimulated an increase in normal anxiety, particularly among the more vulnerable and especially those with a previous history.
Abstract: This article reviews a number of studies which have examined the possible impact of political violence on psychiatric morbidity in Northern Ireland. A brief introduction outlining the way in which the violence has varied spatially, quantitatively and qualitatively since 1969 also draws attention to other possible stressors in Northern Irish society. This is followed by a detailed review of studies which have analysed either admission and referral rates, suicide and attempted suicide rates, trends in psychotropic drug prescribing or data from community-based studies. The criticism is made that several of the early studies did not pay enough attention to important sociodemographic factors and therefore are open to interpretations other than those originally proposed. Nevertheless some agreement does emerge suggesting that it is unlikely that the political violence caused any marked increase in serious psychiatric illnesses but rather stimulated an increase in normal anxiety, particularly among the more vulnerable and especially those with a previous history. Further recent research has begun to suggest that denial of the seriousness of the violence may be one of the mechanisms being used to enable people in Northern Ireland to cope with this continuing problem.

26 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202332
202268
202175
202058
201960
201876