Topic
Psychotropic drug
About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.
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TL;DR: OLP affected mma to a greater extent than CPZ, and caused the greatest interaction at surface pressure of 30 mN/m at higher temperatures, which may indicate that there is poor correlation between side effects and effects of the drugs on phospholipid monolayers.
22 citations
TL;DR: Comparing the psychotropic prescribing patterns of primary care practitioners with psychiatrists and other office‐based specialists in both the early and mid 1980s indicates that primary care practioners were by far the largest prescribers of psychotropic drugs for patients 55 and over at both time periods.
Abstract: Primary care practitioners are significant providers of mental health services to older Americans. The most common mental health service provided by primary care practitioners to this segment of the population is psychotropic drugs. A USA national data base was analyzed to compare the psychotropic prescribing patterns of primary care practitioners with psychiatrists and other office-based specialists in both the early and mid 1980s. Prescribing patterns for six different classes of psychotropics were contrasted for patients 55 years of age and older and those 15-54. Results indicate that primary care practioners were by far the largest prescribers of psychotropics for patients 55 and over at both time periods. This pattern held for most of the individual psychotropic drug classes. In contrast to psychiatrists, primary care practitioners infrequently included a mental disorder diagnosis when they prescribed a psychotropic drug. In addition, primary care practitioners included a mental disorder diagnosis less frequently when they prescribed for the older group than when they prescribed for the younger group. These findings may be used to benefit the training of non-psychiatrist physicians in the diagnosing and treating of mental health disorders found among older adults.
22 citations
TL;DR: The EEG frequency power spectrum clearly showed a gradual increase of the alpha wave spectrum and a gradual decrease of the delta wave spectrum after initiation of the infusion of the amino acid solution.
Abstract: Psychotropic action of a branched-chain-enriched amino acid solution (Aminoleban) was quantitatively and visually examined in six cirrhotic patients with mild hepatic encephalopathy (grades I and II) using electrophysiological and psychometric methods. Neurophysiological effects of the amino acid solution were observed by comparing topographic spectrum analyses of electroencephalography (EEG) before and immediately after an intravenous 3 h infusion of the solution. The delta wave in the frontal region diminished from 61 +/- 13 to 12 +/- 4% (P < 0.01) and the alpha wave in the occipital region increased from 11 +/- 3 to 51 +/- 11% (P < 0.01). Latencies of the P3 wave in visual evoked potentials, which were topographically recorded in the occipital region, shortened from 220 +/- 32 to 148 +/- 19 ms (P < 0.01). Latencies of the P300 wave in event-related potentials, which were topographically recorded in the centro-temporal region, shortened from 493 +/- 81 to 360 +/- 93 ms (P < 0.05). Topographic reaction pattern of P300 was irregular toward the occipital or parietal region in cirrhotic patients. The EEG frequency power spectrum, illustrated by the colour density spectral array of computer-aided polysomnography analysis, clearly showed a gradual increase of the alpha wave spectrum and a gradual decrease of the delta wave spectrum after initiation of the infusion. These immediate neurophysiological changes were confirmed by improvement of quantitative psychometric tests including number connection test, reaction time to sound, and digit symbol and block design tests of Wechsler Adult Intelligence Scale.(ABSTRACT TRUNCATED AT 250 WORDS)
22 citations
TL;DR: The results of this review indicate that rhabdomyolysis in psychiatric patients can be from multiple etiologies, including agitation, dehydration, and intramuscular injections, as well as an adverse effect of psychotropic medications.
Abstract: OBJECTIVE:The objective of this review is to discuss the pathophysiology and potential etiologies of rhabdomyolysis in psychiatric patients, with an emphasis on psychotropic drug-induced rhabdomyolysis.DATA SOURCES:References were obtained through an on-line search of MEDLINE, using English-language and human literature only.STUDY SELECTION:Because the topic is a potential drug-induced adverse effect, no controlled studies are available. Most of the literature are case reports and series of case reports.DATA EXTRACTION:The quality of case reports was assessed using the Food and Drug Administration guidelines for assessing the causality of a potential adverse drug reaction.DATA SYNTHESIS:The results of this review are based on qualitative data and indicate that rhabdomyolysis in psychiatric patients can be from multiple etiologies, including agitation, dehydration, and intramuscular injections, as well as an adverse effect of psychotropic medications. Although the deficiencies of this type of data are reco...
22 citations
01 Sep 1988
TL;DR: Urban-rural differences in psychotropic drug prescribing were examined by comparing data from general practices in two contrasting areas of northern Italy and found patients attending the urban doctors were 1.5 times more likely to be prescribed a psychotrop drug than their rural counterparts.
Abstract: Urban-rural differences in psychotropic drug prescribing were examined by comparing data from general practices in two contrasting areas of northern Italy. Patients attending the urban doctors were 1.5 times more likely to be prescribed a psychotropic drug than their rural counterparts. We also explored urban-rural differences in factors influencing psychotropic prescribing. Such influences were more numerous and complex in the urban than the rural setting.
21 citations