Topic
Psychotropic drug
About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.
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TL;DR: Interesting relationships were observed between amphetamine initial rate of entry into the blood stream and both incidence of side effects (S.E.) and rise in arterial blood pressure.
Abstract: Following an integrated approach based on the contemporary recording of drug plasma levels, central (CNS) and peripheral responses and performance tests, the effects of two different amphetamine formulations were evaluated in healthy volunteers.
16 citations
Journal Article•
TL;DR: "De novo" absence status of late onset is characterized by toxic or metabolic precipitating factors in middle-aged or elderly subjects with no previous history of epilepsy, most often of extra-temporal origin.
16 citations
01 Jan 2013
TL;DR: This chapter discusses how to make Effective Evaluation of Psychotropic Drug Effects in People with Developmental Disabilities and Self-injurious Behavior and Components of a Private School Program Serving Children and Adolescents with Severe Problem Behavior.
Abstract: 1. Introduction -- Part I: Organizational Preparedness -- 2. Importance of Organizational Infrastructure -- 3. Peer Review -- 4. Evidence-Based Practice and Crisis Intervention -- 5. Empirically-Supported Staff Selection, Training, and Management Strategies -- 6. The Use of Protective Equipment in the Management of Severe Behavior Disorders -- 7. Therapeutic Restraint and Protective Holding -- Part II: Crisis Identification and Acknowledgement -- 8. Assessment of Problem Behavior -- 9. Functional Analysis of Problem Behavior -- 10. Assessment of Pediatric Feeding Disorders -- 11. Unique Considerations of Prader-Willi Syndrome -- 12. The Motivation for Self-Injury: Looking Backward to Move Forward -- 13. Co-occurring Psychiatric Disorders in Individuals with Intellectual Disability -- 14. Involving Family in the Prevention and Intervention of Behavior Problems in Individuals with Intellectual and Developmental Disabilities -- Part III: Navigating the Continuum of Care -- 15. Legal and Ethical Issues -- 16. Less to More Restrictive Settings: Policy and Planning Considerations -- 17. How to Make Effective Evaluation of Psychotropic Drug Effects in People with Developmental Disabilities and Self-injurious Behavior -- 18. Consultation in Public School Settings -- 19. Home-Based Services -- 20. Components of a Private School Program Serving Children and Adolescents with Severe Problem Behavior -- 21. Treating Severe Problem Behavior within Intensive Day-Treatment Programs -- 22. Intensive Treatment of Pediatric Feeding Disorders -- 23. Outpatient Units -- 24. Intensive Outpatient Services -- 25. Do Good, Take Data, Get a Life, and Make a Meaningful Difference in Providing Residential Services.
16 citations
TL;DR: The amount of change due to discontinuation of these drugs and adjustment in dosage levels challenges the stereotype of the "neglected psychotropic drug user" in nursing homes.
Abstract: In this longitudinal study of patterns of use of psychotropic drugs by a cohort of elderly nursing home residents (N = 5,752), drug use was examined upon admission, 3 months later, and at discharge/end of study. At each time point, 17% of the cohort used neuroleptics. Half of the subjects discontinued neuroleptics at each time point; however, a similar number were initiated on the drug. Benzodiazepines were used by 21%, 15%, and 15% at each of the three time points, respectively. Twice as many people were taken off benzodiazepines as initiated on them following admission. The 5% rate of antidepressant use was constant across the three time periods, although only half of those who took antidepressants upon admission were also taking them upon discharge/end of study. The amount of change due to discontinuation of these drugs and adjustment in dosage levels challenges the stereotype of the "neglected psychotropic drug user" in nursing homes.
16 citations
TL;DR: The findings suggest that the effects of combination psychotropic drug treatment on HRV are mainly due to their anticholinergic properties, and CV is a useful indicator to assess the parasympathetic activity of psychiatric patients under combination psychotrop drug treatment.
Abstract: The aim of this study was to evaluate the effects of combination psychotropic drug treatment on heart rate variability (HRV), which was mainly controlled by the parasympathetic nervous system. Mean R–R intervals (mRR) and coefficient of variation (CV), an index of HRV, were studied in 22 psychiatric patients and 21 age- and sex-matched healthy controls. Next, in the patient group focusing on both anticholinergic and antidopaminergic properties, combination psychotropic drug daily doses were converted into biperiden milligram equivalents (BPDeq) and chlorpromazine milligram equivalents (CPZeq), respectively. The relationship between mRR and CV and these equivalent dosages was examined. A significant reduction in both mRR (P < 0.05) and CV (P < 0.05) was found in the patient group. In addition, significant negative correlations were observed between the dose of BPDeq and mRR (P < 0.05), and between the dose of BPDeq and CV (P < 0.005). In contrast, no significant correlations were observed between the dose of CPZeq and either parameter. These findings suggest that the effects of combination psychotropic drug treatment on HRV are mainly due to their anticholinergic properties. Therefore, CV is a useful indicator to assess the parasympathetic activity of psychiatric patients under combination psychotropic drug treatment.
16 citations