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Psychotropic drug

About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.


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Journal ArticleDOI
TL;DR: There is an adequate range of psychotropic drugs available to safely treat the pregnant or lactating woman who is mentally ill and close collaboration between obstetrician and psychiatrist is recommended before treatment of a mental illness with psychotropic medication.
Abstract: Although few psychotropic drugs are known to be teratogenic or to have adverse effects on the developing fetus or neonate, no psychotropic drug is of proven safety. It is therefore very important that psychotropic medication should not be prescribed lightly during pregnancy or lactation and that such drugs should be prescribed only where there are positive indications for their use. Close collaboration between obstetrician and psychiatrist is recommended before treatment of a mental illness with psychotropic medication. Breast feeding should not routinely be suspended in mothers who require psychotropic medication. There is an adequate range of psychotropic drugs available to safely treat the pregnant or lactating woman who is mentally ill.

11 citations

Journal ArticleDOI
TL;DR: In order to better support routine TDM in child- and adolescent psychiatry, future work must improve in aspects of study design, execution and reporting to demonstrate drug concentration-effect relationships, and the quality criteria proposed in this work can guide future TDM research.
Abstract: Introduction: The use of psychotropic drugs in children and adolescents is widespread but associated with suboptimal treatment effects. Therapeutic drug monitoring (TDM) can improve safety of psychotropic drugs in children and adolescents but is not routinely performed. A major reason is that the relationship between drug concentrations and effects is not well known. Areas covered: This systematic review evaluated studies assessing the relationship between psychotropic drug concentrations and clinical outcomes in children and adolescents, including antipsychotics, psychostimulants, alpha-agonists, antidepressants, and mood-stabilizers. PRISMA guidelines were used and a quality assessment of the retrieved studies was performed. Sixty-seven eligible studies involving 24 psychotropic drugs were identified from 9,298 records. The findings were generally heterogeneous and the majority of all retrieved studies were not of sufficient quality. For 11 psychotropic drugs, a relationship between drug concentrations and side-effects and/or effectiveness was evidenced in reasonably reported and executed studies, but these findings were barely replicated. Expert opinion: In order to better support routine TDM in child- and adolescent psychiatry, future work must improve in aspects of study design, execution and reporting to demonstrate drug concentration-effect relationships. The quality criteria proposed in this work can guide future TDM research. Systematic review protocol and registration PROSPERO CRD42018084159.

11 citations

Patent
24 Dec 2003
TL;DR: A Chinese medicine as the mate of antipsychotics for lowering their toxic by-effect and improving the tolerance of patient is prepared from 17 Chinesemedicinal materials including liquorice root, American ginseng, earthworm, wolfberry fruit, etc.
Abstract: A Chinese medicine as the mate of antipsychotics for lowering their toxic by-effect and improving the tolerance of patient is prepared from 17 Chinese-medicinal materials including liquorice root, American ginseng, earthworm, wolfberry fruit, etc.

11 citations

Book ChapterDOI
01 Jan 1979
TL;DR: The total prescribing for patients aged over 65 years is reviewed, some examples linking the authors' psychotropic prescribing for the elderly to the relevant clinical indication are given and practice-based data are linked to therelevant clinical information within the computerised record system CLINICS.
Abstract: Most surveys of primary care prescribing have examined prescriptions without reference to the clinical situation. This is because prescription forms (EC10/FP10) have been examined after dispensing by the retail pharmacist. This includes the notable work of Parish and his colleagues (Parish et al 1976). Our data are practice-based and linked to the relevant clinical information within our computerised record system CLINICS (Clark, 1977). Skegg and his colleagues have shown (Skegg, Doll and Perry, 1977) that psychotropic drug prescribing rises sharply with age.In this survey I briefly review our total prescribing for patients aged over 65 years and give some examples linking our psychotropic prescribing for the elderly to the relevant clinical indication.

11 citations

Journal ArticleDOI
TL;DR: 2-AG signaling emerges as a surprisingly strong negative modulator of aggressiveness, which warrants further studies into its general role in social behavior and the target receptors involved.
Abstract: Endocannabinoids are strong modulators of emotionality and present a novel target for psychotropic drug development. Increasing evidence suggests that endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) affect behavior differentially. While the roles of anandamide have been investigated extensively, studies regarding the specific roles of 2-AG became possible only recently, and its involvement in social behaviors has not yet been studied. We studied the impact of 2-AG signaling on aggression as a first attempt to characterize the role of this endocannabinoid in social behaviors. 2-AG signaling was enhanced by the monoacylglycerol lipase inhibitor JZL184 (8, and 16 mg/kg) in mice later submitted to the resident/intruder paradigm. JZL184 near completely abolished aggressiveness in residents and increased victimization (i.e., attacks by the opponent). Interestingly, the level of defensiveness remained unaltered, despite the large increase in bites received. The CB1 receptor blocker AM251 (0.5 mg/kg) did not influence the effects of JZL184. In intruders, JZL184 near completely suppressed bites and offensive behavior in a fashion similar to residents, but it also increased agitation and defensiveness during, and the corticosterone response to, aggressive encounters. Experiments involving the corticosterone synthesis inhibitor metyrapone (30 mg/kg) suggest that the suppression of biting and offensive behavior is directly influenced by JZL184, whereas increased agitation and defensiveness (seen in intruders only) are a secondary development of the stress-endocrine effects of JZL184. 2-AG signaling emerges as a surprisingly strong negative modulator of aggressiveness, which warrants further studies into its general role in social behavior and the target receptors involved.

11 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202332
202268
202175
202058
201960
201876