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Psychotropic drug
About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.
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TL;DR: A simple and rapid high-performance liquid chromatographic method is described for the quantitative analysis of the psychotropic drug minaprine and three of its metabolites, including one as yet undetected metabolite known as a monoamine oxidase type A inhibitor in vitro.
9 citations
TL;DR: In this article , the authors used data from the effectiveness of guideline for dissemination and education in psychiatric treatment (EGUIDE) project to evaluate the presence or absence of psychotropic PRN prescription at the time of discharge, the age and sex of patients receiving PRNs for each diagnosis, and the association between PRNs prescription and regular daily psychotropics.
9 citations
01 Jan 1980
TL;DR: Electroencephalography (EEG), the major method of clinical neurophysiology has widely been used in psychopharmacology, has led to the discovery of “drug-specific” neurophysiological profiles which reflect the changes of brain bioelectric activity induced by a CNS-active drug.
Abstract: Electroencephalography (EEG), the major method of clinical neurophysiology has widely been used in psychopharmacology. It has led to the discovery of “drug-specific” neurophysiological profiles which reflect the changes of brain bioelectric activity induced by a CNS-active drug. Every substance which has a significant effect on human brain function also produces systematic and significant effects on EEG. The changes seen after administration of a CNS-active substance are invariably different from placebo-induced changes; and, what is more important, these are replicable. They follow the same general pattern after repeated administration in the same or even in different populations. Of course, there are intra- and interindividual differences in the neurophysiological response to a certain CNS-active substance, depending obviously on several factors, with the more prominent being the intra- and interindividual “biologic variability.” The group response of several individuals to a therapeutically effective psychotropic drug, however, invariably shows a similar profile on repeated trials (Itil, 1974).
9 citations
TL;DR: In behavioral studies, the stimulant effects of acute caffeine on motor activity were significantly diminished in a dose-dependent manner after chronic caffeine, suggesting the development of tolerance, and chronic caffeine treatment could produce adaptive increases in G protein-stimulated adenylyl cyclase to oppose this effect via G protein regulation.
9 citations
TL;DR: Nomifensin (Hoechst 36984), a synthetic psychotropic drug whose structure differs from MAO inhibitors and tricyclics, was studied in a double blind comparative trial with desimipramine in patients with various depressive syndromes.
Abstract: The effect of nomifensin (Hoechst 36984), a synthetic psychotropic drug whose structure differs from MAO inhibitors and tricyclics, was studied in a double blind comparative trial with desimipramine in patients with various depressive syndromes. Forty-three patients (23 in the nomifensin group and 20 in the desimipramine group) were studied for 6 weeks. Clinical follow-up was done with the Wittenborn scale (WPRS), Hamilton's rating scale for depression (HRS), Zung's scale (SDS), and the PEN inventory. The average daily dose was nomifensin 84 mg and desimipramine 76 mg. Changes in HRS, WPRS and SDS showed statistically significant improvement with both treatments. A moderate anxiolytic effect was found in the nomifensin group, whereas medication had to be discontinued in two desimipramine-treated patients because of its drive-enhancing effect. Urinary phenylethylamine excretion rose in 2 out of 8 patients after 5 weeks of treatment with nomifensin.
9 citations