Topic
Psychotropic drug
About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.
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TL;DR: Key points are discussed regarding clinical, pharmacogenetic, pharmacokinetic, and pharmacodynamic risk factors for treatment-emergent adverse effects, alongside recommendations for their systematic assessment.
6 citations
6 citations
Journal Article•
TL;DR: In older patients, discontinue as many drugs as possible and follow cardiovascular status when in doubt, especially with tricyclic antidepressants as discussed by the authors. But, as mentioned before, discontinuation may not always be the best decision.
Abstract: Alcohol can increase blood levels of diazepam, and probably of other benzodiazepines. Alcohol also potentiates the CNS-depressant effects of these drugs. Before adding a psychotropic drug in older patients, discontinue as many drugs as possible. Prescribe smaller doses and follow cardiovascular status. Determine serum levels when in doubt, especially with tricyclic antidepressants.
6 citations
TL;DR: Non-steroidal anti-inflammatory (NSAI) agents owe their pharmacological activity to the inhibition of prostaglandin biosynthesis (PGBS), and both aspirin and dexamethasone depress the acute inflammatory response to carrageenin in rats.
Abstract: Publisher Summary Prostaglandins are biosynthesized from arachidonic acid. Arachidonic acid serves as a precursor for a virtual cascade of acidic lipids, each possessing distinct and profound pharmacological activities. Prostacycline (PGX) is both a potent inhibitor of platelet aggregation and an arterial vasodilator. The endoperoxides decompose into the fatty acid HHT. This transformation is probably a non-enzymatic artifact and no biological activity. Another fatty acid, HETE, formed from arachidonic acid by a platelet lipoxygenase has been found to exhibit chemotactic activity for neutrophils and eosinophils. Agonists design to exploit the potential therapeutic uses of the prostaglandins. Prostaglandin activities are to modulate the enzymes that control the tissue levels. Anti-inflammatory steroids exhibit potent inhibitory effects on prostaglandin production in rheumatoid synovial. Bradykinin releases prostaglandins from phospholipid in a variety of systems, an effect thought to augment the activities of this peptide. The local anaesthetic tetracaine and psychotropic drug meprobamates are reported to inhibit prostaglandin biosynthesis at the phospholipase level. Non-steroidal anti-inflammatory (NSAI) agents owe their pharmacological activity to the inhibition of prostaglandin biosynthesis (PGBS). Both aspirin and dexamethasone depress the acute inflammatory response to carrageenin in rats. Deplete of arachidonic acid suggests that the activities other than PGBS inhibition contribute to the anti-inflammatory effects of both steroids and NSAl agents. Inhibition of PGBS by a series of NSAl agents appear to be better correlated with the analgesic effects than with the anti-inflammatory activity.
6 citations
Journal Article•
TL;DR: This review is an attempt to depict the general principles and precautions geriatricians, geriatric clinical pharmacologists and geriatric psychiatrists in Geneva, Switzerland have found helpful after many years of interaction with elderly patients and their families, and shared responsibility for the care of these very frail patients.
Abstract: The management of psychotropic drugs is a daily preoccupation for geriatric psychiatrists and geriatricians alike. The lack of controlled clinical trials in very old patients (over 80 years old) often leads to empirical therapy. The multiple somatic co-morbidities of old patients, the high prevalence of potential drug-drug interactions and a wish to implement an increasingly patient centered approach all influence psychotropic drug prescription which tends to be simplified and individualized. This review is an attempt to depict the general principles and precautions we, as in-hospital geriatricians, geriatric clinical pharmacologists and geriatric psychiatrists in Geneva, Switzerland, have found helpful after many years of interaction with elderly patients and their families, and shared responsibility for the care of these very frail patients.
6 citations