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Psychotropic drug
About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.
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TL;DR: The following is a report of the CT findings in three patients who had frontal lobotomies and the correlation of these findings will be compared with the pathological findings in a fourth patient who came to postmortem examination.
4 citations
Journal Article•
TL;DR: Les nouveaux neuroleptiques, antidepresseurs, thymoregulateurs et certaines benzodiazepines ouvrent manifestement des perspectives bien plus favorables au traitement de ces jeunes patients.
Abstract: La psychopharmacologie en psychiatrie de l'adolescence reste aujourd'hui largement determinee par l'experience personnelle de chaque clinicien, son appreciation de l'amelioration clinique et des effets secondaires, et l'extrapolation enfin des etudes realisees chez l'adulte. Cependant quelques etudes medicamenteuses commencent a etre realisees en pedopsychiatrie. Les nouveaux neuroleptiques, antidepresseurs, thymoregulateurs et certaines benzodiazepines ouvrent manifestement des perspectives bien plus favorables au traitement de ces jeunes patients. Mais c'est la qualite du contexte meme de la prescription, la prise en compte des particularites de l'adolescence et de sa psychopathologie: tant pour l'indication que pour mettre en oeuvre et conduire le traitement, qui peuvent garantir la reussite de l'ensemble du traitement. Nous soulignons dans cet article l'interet des prises en charge bifocales pour les adolescents qui presentent les troubles les plus graves et justifient de traitements medicamenteux.
4 citations
TL;DR: Judges should consider Prolixin to be an experimental treatment modality—like psychosurgery—when deciding whether it should be forcibly administered to an involuntarily committed individual.
Abstract: This article examines the psychiatric research and legal doctrine concerning the psychotropic drug Prolixin Decanoate. Prolixin is a unique drug because, once it is injected into a person, its effe...
4 citations
TL;DR: There was a wide variation in the frequency of MS prescriptions between outpatients with schizophrenia in Hong Kong and Beijing, China and use of MSs was associated with a history of violence, number of admissions, study site, sex, and length of illness.
Abstract: Objectives: To date, no studies have investigated the prescription patterns of mood stabilizers (MSs) in Chinese patients with schizophrenia. This study examined the frequency and sociodemographic and clinical correlates of MS prescription for outpatients with schizophrenia in Hong Kong (HK) and Beijing (BJ), China. Methods: Five hundred five clinically stable outpatients with schizophrenia were randomly selected and interviewed in HK and BJ using standardized assessment instruments. Basic sociodemographic and clinical data and psychotropic drug prescriptions were collected at the time of a diagnostic interview. Results: Thirty-four (6.7%) of the patients were prescribed MSs in the whole sample, with 10.2% and 3.2% of the HK and BJ samples, respectively. Use of MSs was associated with a history of violence, number of admissions, and severity of extrapyramidal side effects. In multiple logistic regression analysis, number of admissions, study site, sex, and length of illness were significantly associated with MSs. Conclusions: Although the ethnic and clinical characteristics of the 2 samples were nearly identical, there was a wide variation in the frequency of MS prescriptions between HK and BJ.
4 citations
TL;DR: Fluorine‐19 NMR spectra were acquired from extracts of tissues from heads of rats given the antipsychotic drug trifluoperazine, and multiple resonances in vitro partially explain the relatively large line width seen in vivo for TFP.
Abstract: Fluorine-19 NMR spectra were acquired from extracts of tissues from heads of rats given the antipsychotic drug trifluoperazine (TFP). Contributions to the in vivo 19F spectra from tissues other than brain were negligible. The in vivo 19F resonance at -62.3 ppm from CCl3F consisted of 6–8 resolved resonances in vitro. Some in vitro resonances were assigned to previously identified TFP metabolites. Multiple resonances in vitro partially explain the relatively large line width seen in vivo for TFP. Unidentified metabolites were observed at about -74 to -75 ppm in a number of spectra of extracts of brain and muscle. Magn Reson Med 43:756–759, 2000. © 2000 Wiley-Liss, Inc.
4 citations