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Psychotropic drug

About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.


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Journal ArticleDOI
01 Jan 2016
TL;DR: To ensure more judicious use of psychotropic medications, assessment, and management of patients’ short and long-term outcomes, including clinical evaluation of the benefits and side effects of these drugs are vital.
Abstract: Background: Psychotropic drugs play a huge role in providing care in psychiatric and mental health. The judicious and appropriate use of these medications goes a long way in providing improved quality of health among psychiatric inpatients in Canada. Objective: To appraise the prevalence, pattern, and rational for psychotropic drugs prescription in different psychiatric inpatient settings in Saskatchewan, Canada. Material and methods: We conducted a one-day cross-sectional study at three psychiatric treatment facilities in Saskatchewan, Canada. They were: a) Regional Psychiatric Centre in Saskatoon (RPC); b) Saskatchewan Hospital in North Battleford (SH); and c) Dube Centre for Mental Health in Saskatoon (DC). Data were collected blindly from selected patients’ records in these centres and analyzed using the Statistical Package for Social Science (SPSS) version 21. Results: A total of 381 patients’ records were retrieved and distributed in the three sites; RPC (47.5%), SH (36.5%) and DC (16%). The majority of in-patients were males (76.6%) and between the ages of 25 to 65 years. Schizophrenia was the most Axis 1 DSM-IV psychiatric diagnosis (46.2% counts for all patients) with Saskatchewan Hospital having the highest percentage (61.8%) of patients diagnosed. We calculated a total of 2275 regular prescriptions and 1322 pro re nata (PRN) prescriptions. The mean number of regular and PRN psychotropic medications per patient were 2.83 and 1.38 respectively. The most commonly prescribed drugs were benzodiazepines with Lorazepam being the most prescribed PRN psychotropic drug. Conclusions: To ensure more judicious use of psychotropic medications, assessment, and management of patients’ short and long-term outcomes, including clinical evaluation of the benefits and side effects of these drugs are vital.

4 citations

Journal ArticleDOI
TL;DR: A program of systematic, whole-cell level based, investigation into the role of physical-chemical cellular membrane interactions in the therapeutic action of known psychotherapeutics will complement drug development in psychopharmacology and thereby assist in overcoming the current crisis.

4 citations

Journal ArticleDOI
TL;DR: The prevalence and types of psychotropic drug prescription in primary care for people with dementia are known, and severe adverse events and side effects are common.
Abstract: BACKGROUND: Psychotropic drugs are frequently prescribed to people with dementia in nursing homes although severe adverse events and side effects are common. Less is known about the prevalence and types of psychotropic drug prescription in primary care for people with dementia. OBJECTIVE: This study examined the prevalence of psychotropic drug prescriptions in primary care among persons with dementia from the year of diagnosis onwards. METHODS: A longitudinal observational study using electronic health record (EHR) data was conducted. People with dementia were selected from EHR data of 451 general practices in the Netherlands. Age and gender-adjusted psychotropic drug prescription rates were calculated per 1000 person-years from the year the dementia diagnosis was first recorded in general practice up to 8 years after diagnosis. RESULTS: Data of 15,687 patients were analyzed. The prescription rate of psychotropic drugs (not including antidementia drugs) was 420 per 1000 person-years (95% CI 409; 431) in the first year after the recorded dementia diagnosis, which increased to 801 per 1000 person-years (95% CI 649; 989) in the eighth year. The most frequently prescribed drugs were antidepressants, antipsychotics, and antidementia drugs, followed by anxiolytics, hypnotics, and antiepileptics. CONCLUSIONS: After a dementia diagnosis is recorded in general practice, the prevalence of psychotropic drug prescriptions is substantial and increases steadily during the disease trajectory of persons with dementia. Although the (in)appropriateness of prescribing was not assessed, these insights may stimulate primary care clinicians to (re)consider their prescription policy of psychotropics for people with dementia more carefully.

4 citations

Journal ArticleDOI
TL;DR: The importance of promoting scientific research on drug-drug interactions in psycho-oncology and a closer collaboration between oncologists and psychiatry is outlined in order to reduce the risk of drug- drug Interactions, to increase its awareness and to adequately prescribe a psychopharmacologic treatment for each patient.
Abstract: Introduction: Psychopharmacological treatment is an important tool of the multidimensional approach in oncologic setting but cancer patient´s susceptibility to drug-drug interactions may pose them at risk. Objective: To describe the use of psychotropic in patients referred to a psycho-oncology unit and to point out potential and clinical relevant drug-drug interactions in this context. Methods: Descriptive study of a sample of patients referred for the first time to the Psycho-Oncology Unit of Coimbra University Hospital Centre, between April and December 2013. A retrospective collection of the sociodemographic, clinical and prescription data was made by consulting clinical processes. Results: From the sample of 110 patients, 51,8% of the patients were already taking some psychotropic drug and 91,9% were on antineoplastic medication at the time of the psycho-oncology appointment. Among the psychotropic medication, almost all were benzodiazepines and antidepressants. Psychotropic can cause potential interactions with antineoplastic medication administered in cancer patients. Some pharmacological agents have more potential to cause drug-drug interactions. Conclusions: Prescription of psychotropic medication by the oncological team is common and cancer patients usually take several drugs at the same time. This study outlines the importance of promoting scientific research on drug-drug interactions in psycho-oncology and a closer collaboration between oncology and psychiatry in order to reduce the risk of drug-drug Interactions, to increase its awareness and to adequately prescribe a psychopharmacologic treatment for each patient.

4 citations

Journal ArticleDOI
TL;DR: It is demonstrated that cannabis reduces the Crohn’s disease activity index (CDAI) by >100 points (on a scale of 0–450) and two small studies in ulcerative colitis showed a marginal benefit, however, no improvement was observed in inflammatory markers or in endoscopic score in either disease.
Abstract: Cannabis is the most widely used recreational drug worldwide and is used by some patients with inflammatory bowel disease (IBD) to ameliorate their disease. Whereas epidemiological studies indicate that as many as 15% of IBD patients use cannabis, studies inspecting cannabis use in IBD are few and small. We have conducted several studies looking at the use of cannabis in IBD. In Crohn's disease, we demonstrated that cannabis reduces the Crohn's disease activity index (CDAI) by >100 points (on a scale of 0-450).Two small studies in ulcerative colitis showed a marginal benefit. However, no improvement was observed in inflammatory markers or in endoscopic score in either disease. Many questions regarding cannabis use in IBD remain unanswered. For example, cannabis is a complex plant containing many ingredients, and the synergism or antagonism between them likely plays a role in the relative efficacy of various cannabis strains. The optimal doses and mode of consumption are not determined, and the most common form of consumption, i.e. smoking, is unacceptable for delivering medical treatment. Cannabis is a psychotropic drug, and the consequences of long-term use are unknown. Despite all these limitations, public opinion regards cannabis as a harmless drug with substantial medical efficacy. In Israel, the number of licenses issued for the medical use of cannabis is rising rapidly, as are the acknowledged indications for such use, but good-quality evidence for the effectiveness of cannabis is still lacking. Further studies investigating the medical use of cannabis are urgently needed.

4 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202332
202268
202175
202058
201960
201876