Topic
Psychotropic drug
About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.
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01 Jan 2003
1 citations
01 Jan 2016
TL;DR: Understanding the molecular mechanisms involved in MDMA’s neurotoxicity at the mitochondrial level can be helpful in defining target pathways or molecules mediating these effects, as well as in developing preventive and/or therapeutic approaches for acute or long-lasting neurotoxicity seen in human abusers.
Abstract: 3,4-Methylenedioxymethamphetamine (MDMA; “ecstasy”) is a widely abused psychotropic drug, with stimulant, euphoric, entactogenic, and hallucinogenic properties. Although frequently perceived by consumers as relatively safe, clinical case reports and controlled studies in humans and laboratory animals have documented the neurotoxicity of this drug, by mechanisms not fully disclosed. There is some evidence that mitochondrial-dependent pathways can provide a major understanding concerning the processes underlying MDMA’s neurotoxicity. MDMA promotes inhibition of mitochondrial electron transport chain complexes, perturbations of mitochondrial fusion/fission mechanisms and trafficking, as well as oxidative modifications in mitochondrial macromolecules. Understanding the molecular mechanisms involved in MDMA’s neurotoxicity at the mitochondrial level can be helpful in defining target pathways or molecules mediating these effects, as well as in developing preventive and/or therapeutic approaches for acute or long-lasting neurotoxicity seen in human abusers.
1 citations
TL;DR: This book might be considered a text in the field now called psycho-oncology, and Dr. Straker presents cogent reasons why these formal methods should be altered in the care of the dying patient.
1 citations
TL;DR: Patients with BPD present a large variety of symptoms, high rates of comorbid conditions, substantial use of healthcare resources and constitute a significant social and economic burden and polypharmacy is common.
1 citations
TL;DR: Drug prescriptions were studied in two samples of inpatients that differentiated by their ages, in order to compare the use of psychotropic and non‐psychiatric drugs, and the proportion of newer versus classical antidepressants or antipsychotics.
Abstract: Background: Drug prescriptions were studied in two samples of inpatients that differentiated by their ages (patients 18–64 years vs elderly patients >64 years), in order to compare the use of psychotropic and non-psychiatric drugs, and the proportion of newer versus classical antidepressants or antipsychotics.
Methods: Drug prescriptions were recorded on a reference day in May 2000 in two hospitals that differed in the age categories of the patients who were admitted. The total costs per patient were compared, as well as the proportion of those due to a somatic medication.
Results: The prescriptions of 61 adult patients and of 82 psychogeriatric patients were assessed. The mean number of prescribed somatic drugs per patient was higher in elderly patients (P < 0.001), which was again reflected in a higher mean number of all drugs jointly (P < 0.001). Prescription of benzodiazepines was lower in elderly patients than in the adult patients (P < 0.001), even when used as an add-on treatment with antidepressants (P < 0.001). The pharmacological treatment of adult patients was significantly less expensive (9.3 ± 7.2 Swiss Francs/patient) than that of the psychogeriatric patients (14.1 ± 9.5 Swiss Francs/patient; P = 0.009), who had a higher need for somatic comedications.
Conclusions: This survey confirms the large impact of local traditions on the prescription habits of clinicians, with the exception of the prescription of benzodiazepines, regarding which psychiatrists of psychogeriatric patients seem to be less enthusiastic.
1 citations