Topic
Psychotropic drug
About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.
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TL;DR: The issue of psychotropic drug treatment of depression in epilepsy is interlinked with that of worsening seizures, and the potential neurobiological and psychosocial determinants, epilepsy-related variables and the antiepileptic drug treatment are discussed.
Abstract: In patients with epilepsy, mood disorders represent a frequent psychiatric comorbidity but they often remain unrecognized and untreated. However, comorbid depression may have a major impact on the quality of life of patients with epilepsy, sometimes even more than the seizures. Among the potential neurobiological and psychosocial determinants, epilepsy-related variables (age at onset of seizures, temporal lobe epilepsy and frequency of seizures) and the antiepileptic drug treatment have been associated with depression. Nonetheless, data on treatment strategies are still limited with a lack of controlled trials on the use of antidepressant drugs. Moreover, the issue of psychotropic drug treatment of depression in epilepsy is interlinked with that of worsening seizures. This paper is aimed at discussing all these subjects in the light of current literature on the neurobiology of depression in epilepsy.
62 citations
TL;DR: Persistence of depression was positively associated with initially reporting cognitive and affective types of depressive symptoms, the presence of physical illness, the seeking of psychiatric treatment, and the receipt of psychotropic drug prescriptions.
Abstract: This exploratory study examines the persistence of depressive symptomatology as measured by the Center for Epidemiological Studies Depressive Scale (CES-D). Over as 12-month period, half of the group of 309 prepaid group practice enrollees reporting depressive symptoms at the beginning of the interval also had high scores on the CES-D at the end of the interval. Sociodemographic characteristics did not predict persistence of depression. Persistence of depression was positively associated with initially reporting cognitive and affective types of depressive symptoms, the presence of physical illness, the seeking of psychiatric treatment, and the receipt of psychotropic drug prescriptions.
62 citations
TL;DR: This paper examines several issues that policymakers should consider when addressing formulary design for psychotropic drugs: heterogeneity within mental health disorders and limited information about treatment effectiveness for individual patients; the potential for plans to try to use formularies to avoid adverse selection and implications for psychotrop coverage.
Abstract: Payers of pharmaceutical benefits are increasingly turning to drug formularies in an attempt to control rising pharmacy costs, including those for psychotropic drugs. In this paper I examine several issues that policymakers should consider when addressing formulary design for psychotropic drugs: heterogeneity within mental health disorders and limited information about treatment effectiveness for individual patients; the potential for plans to try to use formularies to avoid adverse selection and implications for psychotropic coverage; the interaction of Medicaid formulary policy and manufacturers’ incentives for psychotropic innovation; and incentives created by mental health institutions that decrease formularies’ potential effectiveness in controlling psychotropic drug costs.
62 citations
TL;DR: The main steps of biological degradation of the drug are reduction of the keto group at C 2 oxidation at position 2′ of the isobutyl side chain selective ether cleavage at C 9 , followed by conjugation of the phenols to glucuronic acid and the same pattern of metabolite formation was observed in the rabbit, in the dog and in man.
62 citations
TL;DR: It is not possible using the Skinner box to say whether neuroleptics control fear because they have a basic anorexiant effect in laboratory animals, but the evidence suggests that these sedatives act by controlling fear.
Abstract: 1.
Various measurements have been made of the change in food rewarded behaviour due to drugs.
2.
Some sedatives enhance food rewarded behaviour in solitary rats. The Skinner box is a sensitive method of demonstrating this.
3.
The evidence suggests that these sedatives act by controlling fear.
4.
It is not possible using the Skinner box to say whether neuroleptics control fear because they have a basic anorexiant effect in laboratory animals.
62 citations