Psychotropic drug

About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.

Psychotropic drug use in the Norwegian general population in 2005: data from the Norwegian Prescription Database

Abstract: PURPOSE: To analyse psychotropic drug utilisation patterns in the general population of Norway in 2005. METHODS: Data on 4 163 045 prescriptions of psychotropic drugs dispensed at all pharmacies in Norway during 2005 were extracted from The Norwegian Prescription Database (NorPD), including antipsychotics (ATC-code N05A), anxiolytics (N05B), hypnotics (N05C) and antidepressants (N06A). This information was merged with data concerning the 3857 general practitioners (GPs) from the Norwegian Regular GP Scheme. RESULTS: A total of 705 230 individuals, or 15.3% of the general population, received at least one prescription of a psychotropic drug. The figures for the four therapeutic subgroups were 2.4% for antipsychotics, 6.2% for anxiolytics, 7.9% for hypnotics and 6.0% for antidepressants, respectively. For all subgroups, prevalence was higher among women than among men, and increased steadily by patients' age. The mean annual drug volume per patient was highest among persons aged 40-59 years, except for hypnotics where it continued to increase with age. GPs prescribed 80% of overall psychotropic drug volume, psychiatrists 5%, and other prescribers 15%. The proportion of the drugs issued by the three prescriber groups differed with the patients' age group. While children and adolescents received a relatively large share from paediatricians and child and adolescent psychiatrists, adults mostly got their prescriptions from GPs. CONCLUSIONS: The majority of psychotropic drugs were prescribed by GPs. Overall drug use increased significantly, and psychiatrists' contribution decreased significantly with patients' age. The quality of pharmacological treatment for mental health problems of the general and aging population therefore relies mainly on the GPs. Copyright (c) 2009 John Wiley & Sons, Ltd. Language: en

Carbamazepine can induce kidney water absorption by increasing aquaporin 2 expression.

Abstract: Background. Carbamazepine (Carba) is an anticonvulsant and psychotropic drug used widely for the treatment of intellectual disability and severe pains, but the incidence of hyponatremia is a common related occurrence. This hyponatremia is frequently attributed to a SIADH induced by this drug. It is also known that Carba is used to decrease the urinary volume in Diabetes Insipidus (DI) because it has an antidiuretic effect. Lithium (Li) is one of the most important drugs used to treat bipolar mood disorders. However Li has the undesirable capacity to induce DI. Nowadays, the association of these drugs is used in the treatment of patients with psychiatric and neurological problems. Methods. In vivo and in vitro (microperfusion) experiments were developed to investigate the effect of Carba in the rat Inner Medullary Collecting Duct (IMCD). Results. The results revealed that Carba was able to stimulate the V2 vasopressin receptor-Protein G complex increasing the water permeability (Pf) and water absorption. In vivo studies showed that in rats with lithium-induced DI, Carba decreased the urinary volume and increased the urinary osmolality. AQP2 expression was increased both in normal IMCD incubated with Carba and in IMCD from lithium-induced DI after Carba addition to the diet, when compared with the control. Conclusion. These results showed that the hyponatremia observed in patients using this anticonvulsant drug, at least in part, is due to the Carba capacity to increase IMCD's Pf and that the Lithium-Carbamazepine association is beneficial to the patient.

Influence of social problems on management in general practice: multipractice questionnaire survey

Abstract: Objectives: To find how often social problems influence clinical management in general practice, how management is changed, and how the characteristics of patients, doctors, and the doctor-patient relationship influence this management. Design: Multipractice survey of patients consulting general practitioners. Doctors completed a questionnaire for each patient. Setting: General practices in Buskerud county, Norway. Subjects: 1401 consecutive adult patients attending 89 general practitioners. Main outcome measures: How often management of patients was influenced by different types of social problem and main reasons for consultation; frequency and intercorrelation of different types of management applied; odds ratios for social problems9 influence on management, controlled for by characteristics of doctors, patients, and their relationship. Results: In 17% of all consultations the doctors9 knowledge of patients9 social problems influenced their management, stressful working conditions being the most frequent influencing type of problem. Knowledge of social problems influenced management more often when the doctor knew a patient well, but less often the longer a doctor had worked in a practice. When social problems influenced management, the commonest types of management offered were extra time for consultation (51%), advice (42%), authorisation of sick leave (28%), and prescription of a psychotropic drug (20%), while referral to community services was used in 2.6% of these consultations. Prescription of a psychotropic drug was positively correlated with use of extra time, and was made more often by female doctors. Conclusions: Patients9 social problems influenced choice of management in at least a sixth of consultations. Prior knowledge of the patient, the doctor9s time in present practice, age and sex of the patient, and sex of the doctor significantly influenced management of patients.

Psychotropic drug side effects : clinical and theoretical perspectives

Abstract: Differential diagnosis of: fever acute pneuonitis infectious causes of cerebrospinal fluid pleocytosis infectious causes of bacteriuria and pyuria infectious causes of diarrhea infectious causes of rash infectious monoarthritis infectious polyarthritis infectious causes of jaundice infectious causes of splenomegaly infectious causes of localized and generalized lymphadenopathy infection in the compromised host AIDS haematologic changes associated with infections sources and transmission of infectious diseases.

Trends in the use of psychotropic drugs in Taiwan: a population-based national health insurance study, 1997-2004.

Abstract: Objective: This study examined changes in the use of psychotropic agents in Taiwan between 1997 and 2004. Methods: The population-based National Health Insurance database was used to detect trends in the use of psychotropic drugs in Taiwan. A dynamic random sample of 200,432 persons was gathered and followed from 1997 to 2004. Persons in the sample who had made at least one service claim during these years for either ambulatory or inpatient care with a psychotropic drug prescription were identified. Results: The prevalence of any psychotropic drug use increased from 7.1% in 1997 to 12.0% in 2004. The changes in prevalence of use of four kinds of psychotropic drugs from 1997 to 2004 were as follows: antipsychotics, 3.4% to 3.7%, although this finding was not significant; antidepressants, 2.2% to 4.4% (p<.001); mood stabilizers, .6% to 1.3% (p<.001); and anxiolytichypnotic drugs, 3.0% to 7.3% (p<.001). Conclusions: Overall, the prevalence of use of three kinds of psychotropic drugs (antidepressants, mood stabilizers, and anxiolytic-hypnotic drugs) increased greatly from 1997 to 2004. (Psychiatric Services 58: 554–557, 2007)