Psychotropic drug

About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.

Incident hip fractures among community dwelling persons with Alzheimer's disease in a Finnish nationwide register-based cohort.

Abstract: Background Previous cohort studies have shown that persons with Alzheimer’s disease (AD) have a higher risk of hip fractures but recent data from large representative cohorts is scarce. Methods We investigated the association between AD and prevalent and incident hip fractures in an exposure-matched cohort study conducted in Finland 2002–2009 (the Medication and Alzheimer’s disease in 2005 study; MEDALZ-2005). The study population included all community-dwelling persons with verified AD diagnosis in Finland on December 31, 2005 and one matched comparison person per AD case (N = 56,186, mean age 79.9 (SD 6.8) years, range 42–101 years). The diagnosis of AD was extracted from a special reimbursement register. Data on hip fractures during 2002–2009 was extracted from the Finnish National hospital discharge register. Analyses of incident hip fractures (n = 2,861) were restricted to years 2006–2009. Results Persons with AD were twice as likely to have previous hip fracture in 2005 (odds ratio, 95% confidence interval 2.00, 1.82–2.20) than matched aged population without AD. They were also more likely to experience incident hip fracture during the four-year follow-up (hazard ratio, 95% confidence interval 2.57, 2.32–2.84, adjusted for health status, psychotropic drug and bisphosphonate use). The AD-associated risk increase decreased linearly across age groups. Although people with AD had higher risk of hip fractures regardless of sex, the risk increase was larger in men than women. Conclusion Findings from our nationwide study are in line with previous studies showing that persons with AD, regardless of sex or age, have higher risk of hip fracture in comparison to general population. Although there was some suggestion of effect modification by age or sex, AD was consistently associated with doubling of the risk of incident hip fracture.

Physical ill-health and psychotropic drug prescription--a review.

Abstract: This review collates evidence of substantial physical morbidity in patients who receive psychotropic drugs, and evidence that these drugs are not infrequently prescribed for patients with known physical illness. Minor tranquillizers are the psychotropic drugs most commonly prescribed, and the category of physical illness most likely to be associated with psychotropic medication is cardiovascular disease.

Ethnomedicine and drug discovery

Abstract: Introduction, M. Iwu drugs from nature - past achievements, future prospects, G. Cragg, D.J. Newman natural products for high throughput screening, A.L. Harvey medical ethnobotanical research as a method to identify bioactive plants to treat infectious diseases, T.J.S. Carlson development of Herbmedr, an interactive, evidence-based herbal database, J. Wootton natural products - a continuing source of inspiration for the medicinal chemist, S. Mbua Ngale Efange integrating African ethnomedicine into primary healthcare - a framework for South-Eastern Nigeria, Chioma Obijiofor current initiatives in the protection of indigenous and local community knowledge - problems, concepts and lessons for the future, R. Lettington bioprospecting - using Africa's genetic resources as a new basis for economic development and regional cooperation, A. Onugu balancing conservation with utilization - restoring populations of commercially valuable medicinal herbs in forests and agroforests, R.A. Cech ethnomedicine of the Cherokee - historical and current applications, J. Jo traditional medicines and the new paradigm of psychotropic drug action, E. Elisabetsky drug discovery through ethnobotany in Nigeria - some results, J.I. Okogun plants, products and people - Southern African perspectives, N. Gericke development of antimalarial agents and drugs from parasitic infections based on leads from traditional medicine - the Walter Reed experience, B.G. Schuster health foods in anti-aging therapy - reducers of physiological decline and degenerative diseases, L. Meserole indigenous peoples and local communities embodying traditional lifestyles. (Part Contents). definitions under article 8(j) of the Convention on Biological Diversity (K. Moran). 17. Garcinia kola a new look at an old adaptogenic agent (M.M. Iwu, A. Duncan Diop, L. Meserole, C.O. Okunji). 18. Linking intellectual property rights with traditional medicine (M.A. Gollin). 19. The use of conservation trust funds for sharing financial benefits in bioprospecting projects (M. Guerin-McManus, K.C. Nnadozie, S.A. Laird).

Psychotropic drug use in Northern Ireland 1966–80: prescribing trends, inter- and intra-regional comparisons and relationship to demographic and socioeconomic variables

Abstract: A study of psychotropic drug prescribing, derived from the computerized pricing data in Northern Ireland from 1966, showed that the use of these drugs reached a peak in 1975, when about 12.5% of the adult population were estimated to have been receiving them, and declined in the following 5 years. Benzodioazepines accounted for three-quarters of all psychotropic drugs prescribed in 1980. Benzodiazepine tranquillizer prescribing was consistently 20-30% higher than in the rest of the United Kingdom, in contrast to hypnotic and antidepressant prescribing which has been consistently lower. The rate of increase in benzodiazepine tranquillizer prescribing was greater than in other European countries, but the level remains lower than in Iceland and Denmark. The influence of a number of demographic and socioeconomic variables was studied in an intra-regional analysis of the 1978 data for the 17 health districts in the province, using multivariate and multiple regression statistics. The prescribing of benzodiazepine hypnotics was almost entirely accounted for by the proportion of elderly (over 65 years) and women aged 45-59 years: neuroleptic prescribing was largely a function of factors associated with rural areas (overcrowding and unemployment) and the proportion of elderly; but neither tranquillizer, antidepressant, barbiturate hypnotic nor psychostimulant prescribing were satisfactorily explained by these variables.