Topic
Psychotropic drug
About: Psychotropic drug is a research topic. Over the lifetime, 2309 publications have been published within this topic receiving 54070 citations.
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TL;DR: In this paper, the suspension polymerization method was used for synthesis of the nano-composite between Molecularly Imprinted Polymers (MIP) and Multiwall Carbon Nanotubes (MWCNT) for the first time.
Abstract: In this research, the suspension polymerization method was used for synthesis of the nano-composite between Molecularly Imprinted Polymers (MIP) and Multiwall Carbon Nanotubes (MWCNT) for the first time. The chlorpromazine (CPZ) drug was applied as template molecule. The MIP-MWCNT nanocomposite and the non-imprinted polymer (NIP-MWCNT) were used for modification of screen printed carbon electrodes (SPCEs) which were designed and manufactured by hand. The modified SPCEs were used for CPZ determination via a three-step procedure includes: CPZ extraction from sample solution, electrode washing and electrochemical measurement. After ensuring the appropriate response of MIP based sensors to CPZ, the factors affecting the performance of sensor were examined and the calibration curve was constructed under optimized conditions. The peak current showed a linear relationship with CPZ concentration in the range of 7.50 × 10−10–2.50 × 10−7 M (R2 = 0.9956) and the detection limit was calculated 2.96 × 10−10 M. The relative standard deviations for investigation of sensor’s repeatability and reproducibility were obtained 3.76 and 4.13% (n = 5) respectively. Finally, in order to evaluate the sensor’s ability to determination of chlorpromazine in samples with complex matrices, it used for assay of CPZ in tablet and spiked human urine samples.
34 citations
TL;DR: The results suggest that the CDI in an informant-rating version is suitable as a diagnostic and screening instrument for mentally retarded adults.
34 citations
Journal Article•
TL;DR: An interactive effect between social problems and sex on psychotropic drug prescription was found and the perception by the GP of a social problem increases the risk that a psychotropic will be prescribed about twice in women, but not in men.
Abstract: A survey of psychotropic drug prescription was conducted in Verona using information obtained from 92 GPs. A total of 2559 patients consulted their GPs on the day of the study and 14.2% of them received a prescription for a psychotropic drug. Benzodiazepines were the most frequently prescribed: 72.8% and 70.4% of all psychotropic prescriptions in women and men respectively. The prevalence of prescription was higher in women than in men (15.8% vs 11.2%) and the difference was statistically significant (P less than 0.001). Subjects aged 45-64 had the highest chance of receiving prescriptions for psychotropics. Occupational status seems related to psychotropic drug prescription only in women. A strong association was found between psychotropic drug prescription and conspicuous psychiatric morbidity. This association was independent of sex, age, and occupational status. An interactive effect between social problems and sex on psychotropic drug prescription was found. The perception by the GP of a social problem increases the risk that a psychotropic will be prescribed about twice in women, but not in men.
34 citations
TL;DR: The psychotropic drug treatment of the authors' hospital's 220 patients was surveyed, and the findings were compared with those of the only previous hospital survey in this country which showed much allegedly inappropriate prescribing.
Abstract: We surveyed the psychotropic drug treatment of our hospital's 220 patients, and compared our findings with those of the only previous hospital survey in this country which showed much allegedly inappropriate prescribing. Using simple classifications of the patients' diagnoses and of the drugs prescribed, 30 per cent of our prescriptions appeared inappropriate in the absence of knowledge of the patients' symptoms. With such knowledge we show that only 2 of our 460 prescriptions were inappropriate.
34 citations
TL;DR: Because of their lack of oestrogen production, it was anticipated that ArKO mice would display enhanced effects of amphetamine on locomotor activity and PPI, but in these animals, aromatase knockout appeared to be ‘protective’.
Abstract: The aim of the present study was to investigate the possible role of oestrogen in schizophrenia by comparing aromatase knockout (ArKO) mice, which are unable to produce oestrogen, with wild-type controls using two behavioural animal models with relevance to the illness, psychotropic drug-induced locomotor hyperactivity and prepulse inhibition (PPI). Baseline PPI was not different between ArKO and controls. Treatment with apomorphine, MK-801 and amphetamine caused disruption of PPI in all groups. However, in female but not male ArKO mice, the effect of both apomorphine and amphetamine was reduced. In female ArKO mice, amphetamine-induced hyperlocomotion was markedly reduced, but in male mice, the genotype difference was far smaller. Female but not male ArKO mice also showed a reduction of phencyclidine-induced locomotor hyperactivity. The density of dopamine transporters, but not D1 and D2 receptors, was significantly increased in the caudate putamen of male but not female ArKO mice compared to wild-type mice. This could represent a compensatory dopaminergic upregulation in male ArKO mice. Because of their lack of oestrogen production, it was anticipated that ArKO mice would display enhanced effects of amphetamine on locomotor activity and PPI. Instead, in these animals, aromatase knockout appeared to be ‘protective’. This may represent limitations in the ability to model a complex illness such as schizophrenia in a constitutive knockout model, such as ArKO mice. Moreover, the current results may point at the involvement of other sex steroids, which are also altered in ArKO mice, in dopaminergic control of behaviour.
34 citations