Topic
Pulmonary Valve Insufficiency
About: Pulmonary Valve Insufficiency is a research topic. Over the lifetime, 411 publications have been published within this topic receiving 10165 citations.
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TL;DR: It is shown that percutaneous valve replacement in the pulmonary position is possible and with further technical improvements, this new technique might also be used for valve Replacement in other cardiac and non-cardiac positions.
1,028 citations
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TL;DR: The timing of pulmonary valve replacement in adult patients with repaired tetralogy of fallot remains controversial as mentioned in this paper, and a magnetic resonance imaging (MRI) study in 17 adults with T1F showed a statistically significant decrease in right ventricular (RV) volume after surgery from 163 +/- 34 to 107 +/- 26 ml/m2.
Abstract: The timing of pulmonary valve replacement in adult patients with repaired tetralogy of Fallot remains controversial A magnetic resonance imaging study in 17 adult patients with repaired tetralogy of Fallot reveals a statistically significant decrease in right ventricular (RV) volume (RV end-diastolic volume 163 +/- 34 to 107 +/- 26 ml/m2, p 170 ml/m2 or a RV end-systolic volume >85 ml/m2 before pulmonary valve replacement were RV volumes "normalized" after surgery
614 citations
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TL;DR: Right ventricular recovery following PVR for chronic significant pulmonary regurgitation after repair of TOF may be compromised in the adult population and pulmonary valve implant in these patients should be considered before RV function deteriorates.
547 citations
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TL;DR: In this updated report from the multicenter US Melody valve trial, an ongoing high rate of procedural success and encouraging short-term valve function is demonstrated, highlighting the importance of patient selection, adequate relief of obstruction, and measures to prevent and manage stent fracture.
Abstract: Background—Transcatheter pulmonary valve placement is an emerging therapy for pulmonary regurgitation and right ventricular outflow tract obstruction in selected patients. The Melody valve was recently approved in the United States for placement in dysfunctional right ventricular outflow tract conduits. Methods and Results—From January 2007 to August 2009, 136 patients (median age, 19 years) underwent catheterization for intended Melody valve implantation at 5 centers. Implantation was attempted in 124 patients; in the other 12, transcatheter pulmonary valve placement was not attempted because of the risk of coronary artery compression (n=6) or other clinical or protocol contraindications. There was 1 death from intracranial hemorrhage after coronary artery dissection, and 1 valve was explanted after conduit rupture. The median peak right ventricular outflow tract gradient was 37 mm Hg before implantation and 12 mm Hg immediately after implantation. Before implantation, pulmonary regurgitation was moderat...
511 citations
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TL;DR: Percutaneous pulmonary valve implantation is feasible at low risk, with quantifiable improvement in MRI-defined ventricular parameters and pulmonary regurgitation, and results in subjective and objective improvement in exercise capacity.
Abstract: Background— Right ventricular outflow tract (RVOT) reconstruction with valved conduits in infancy and childhood leads to reintervention for pulmonary regurgitation and stenosis in later life. Methods and Results— Patients with pulmonary regurgitation with or without stenosis after repair of congenital heart disease had percutaneous pulmonary valve implantation (PPVI). Mortality, hemodynamic improvement, freedom from explantation, and subjective and objective changes in exercise tolerance were end points. PPVI was performed successfully in 58 patients, 32 male, with a median age of 16 years and median weight of 56 kg. The majority had a variant of tetralogy of Fallot (n=36), or transposition of the great arteries, ventricular septal defect with pulmonary stenosis (n=8). The right ventricular (RV) pressure (64.4±17.2 to 50.4±14 mm Hg, P<0.001), RVOT gradient (33±24.6 to 19.5±15.3, P<0.001), and pulmonary regurgitation (PR) (grade 2 of greater before, none greater than grade 2 after, P<0.001) decreased signi...
461 citations