Topic
Pulsatile flow
About: Pulsatile flow is a research topic. Over the lifetime, 6278 publications have been published within this topic receiving 149638 citations.
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TL;DR: It is demonstrated that tissue engineering of VSM tissues in vitro by using pulsatile perfusion bioreactors and elastic PLCL scaffolds leads to the enhancement of tissue development and the retention of differentiated cell phenotype.
229 citations
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TL;DR: In this paper, an approximate numerical method for calculating flow profiles in arteries is developed, which takes into account the nonlinear terms of the Navier-Stokes equations as well as the non-linear behaviour and large deformations of the arterial wall.
Abstract: An approximate numerical method for calculating flow profiles in arteries is developed. The theory takes into account the nonlinear terms of the Navier-Stokes equations as well as the nonlinear behaviour and large deformations of the arterial wall. Through the locally measured values of the pressure, pressure gradient, and pressure-radius function, the velocity distribution and wall shear at a given location along the artery can be determined. The computed results agree well with the corresponding experimental data.
227 citations
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TL;DR: General agreement between observed and calculated flow curves has been found and so establishes the validity of the theoretical derivation based on general hydrodynamic principles and also justifies the method of recording flows.
Abstract: This paper is concerned with the recording of the phasic changes in arterial flow during each cardiac cycle, and the investigation of the pressure oscillations generating this flow. The relation of pressure to flow is 'the central problem in haemodynamics' (Burton, 1952), and has never been satisfactorily resolved for arterial flow, as its oscillatory nature makes the application of Poiseuille's law invalid. The study has been confined here to the femoral artery of the dog. Direct measurements of flow have been made by following the movement of injected bubbles of oxygen recorded by high-speed cinematography (McDonald, 1952 a). Pressure gradients have been measured by simultaneous recording of arterial pressure at two points in the artery and also by electrical differentiation of the output of a capacitance manometer. Flow curves have been calculated from the gradients using equations derived by Womersley (1954), the theory of which is presented in his accompanying paper (Womersley, 1955). General agreement between observed and calculated flow curves has been found and so establishes the validity of the theoretical derivation based on general hydrodynamic principles and also justifies the method of recording flows. Preliminary accounts have been presented to the Physiological Society both of the flow curves (Helps & McDonald, 1953) and of the derivation of flow from the pressure gradients (Helps & McDonald, 1954).
225 citations
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TL;DR: The experiments indicate that a permanent region of poststenotic flow separation does not exist even for the severest constriction, in contrast to results for steady flow, implying that identification of flow disturbances of an organized nature may be more fundamental in recognizing mild to moderate disease.
224 citations
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TL;DR: In subjects with predominantly systolic and diastolic hypertension, ambulatory mean BP and PP exert a different predictive effect on the cardiac and cerebrovascular complications.
Abstract: Background—We tested the hypothesis that the steady and pulsatile components of blood pressure (BP) exert a different influence on coronary artery disease and stroke in subjects with hypertension. ...
222 citations