Topic
Pylorus
About: Pylorus is a research topic. Over the lifetime, 2843 publications have been published within this topic receiving 47373 citations. The topic is also known as: pyloric part & pyloric orifice.
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TL;DR: The most evident effect of disrupting the neuronal NOS gene is the development of grossly enlarged stomachs, with hypertrophy of the pyloric sphincter and the circular muscle layer.
1,304 citations
Journal Article•
TL;DR: Results in the two patients described are encouraging and further clinical observation and laboratory evaluation will be necessary before this modification of the usual technique of pancreaticoduodenectomy to preserve the pylorus and distal part of the stomach in patients in whom the resection is performed for benign disease or for carcinoma.
Abstract: Further clinical observation and laboratory evaluation will be necessary before we can recommend this modification of the usual technique of pancreaticoduodenectomy to preserve the pylorus and distal part of the stomach in patients in whom the resection is performed for benign disease or for carcinoma of the distal part of the duodenum However, we believe that the early results in the two patients described are encouraging
522 citations
TL;DR: It appeared that in emptying saline, the gastroduodenal system acts as an "open-loop" system passing liquids from the stomach at a rate primarily determined by the volume of gastric contents, while with glucose, a "closed- loop" system is established that assumes a steady-state balance.
435 citations
TL;DR: Findings confirm an increased risk of upper gastrointestinal cancer in the polyposis patient, particularly distal to the pylorus, and support an adenoma-carcinoma sequence.
434 citations
TL;DR: Patients who underwent the duodenum-preserving resection had less pain, greater weight gain, a better glucose tolerance, and a higher insulin secretion capacity up to 6 months after operation for chronic pancreatitis.
Abstract: Background In about 30% of patients, chronic pancreatitis leads to an inflammatory enlargement of the pancreatic head with subsequent obstruction of the pancreatic duct, common bile duct, and duodenum. Methods In a prospective, randomized controlled trial, we compared duodenum-preserving pancreatic head resection (DPPHR) with pylorus-preserving Whipple (PPW) operation to define the advantages of each operation with regard to (1) postoperative complications, (2) glucose tolerance and induction of diabetes mellitus, and (3) postoperative pain and quality of life up to 6 months after operation for chronic pancreatitis. Results The two study groups of 20 patients were both well balanced with regard to sex, age, history of chronic pancreatitis, and indication for surgery. Postoperative mortality was zero. After duodenum-preserving and pylorus-preserving resection, morbidity was 15% and 20%, respectively. After 6 months, patients who underwent the duodenum-preserving resection had less pain, greater weight gain, a better glucose tolerance, and a higher insulin secretion capacity. Conclusion The DPPHR compares favorably with the standard PPW operation and should be considered as an alternative procedure in the treatment of chronic pancreatitis.
418 citations