Topic
Pyranose
About: Pyranose is a research topic. Over the lifetime, 1619 publications have been published within this topic receiving 35348 citations. The topic is also known as: pyranoses & hexopyranose.
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Patent•
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30 May 2008
TL;DR: In this paper, a cellulose ester film with an internal haze of ≤ 5% is presented, and the general formula (I) is as follows: B-(G-A)n-G-B (wherein, B represents aryl-carboxylic acid residue; G represents 2-12C alkylene glycol residue or the like; A represents 4-12c alkyline dicarboxyric acid residue or a like; n is an integer of ≥ 1)
Abstract: PROBLEM TO BE SOLVED: To provide a cellulose ester film excellent in front contrast SOLUTION: In the cellulose ester film having an internal haze of ≤002, the cellulose ester film includes a cellulose ester in which the haze in an ASTM-A solvent is ≤5%, and at least one of an aromatic-terminated polyester-based compound represented by the general formula (I) and an ester compound having 1 to 12 units of at least one of the pyranose structure or the furanose structure, wherein all or a portion of OH groups of each structure is esterified The general formula (I) is as follows: B-(G-A)n-G-B (wherein, B represents aryl-carboxylic acid residue; G represents 2-12C alkylene glycol residue or the like; A represents 4-12C alkylene dicarboxylic acid residue or the like; and n is an integer of ≥1) COPYRIGHT: (C)2010,JPO&INPIT
9 citations
TL;DR: The methods developed in this work give access to molecules that position the three selected binding elements in various 3D orientations on a pyranose scaffold and have been applied for the production of a systematically diverse library of several hundred monosaccharide-based mimetics.
Abstract: The pyranose scaffold is unique in its ability to position pharmacophore substituents in various ways in 3D space, and unique pharmacophore scanning libraries could be envisaged that focus on scanning topography rather than diversity in the type of substituents. Approaches have been described that make use of amine and acid functionalities on the pyranose scaffolds to append substituents, and this has enabled the generation of libraries of significant structural diversity. Our general aim was to generate libraries of pyranose-based drug-like mimetics, where the substituents are held close to the scaffold, in order to obtain molecules with better defined positions for the pharmacophore substituents. Here we describe the development of a versatile synthetic route toward peptide mimetics build on 2-amino pyranose scaffolds. The method allows introduction of a wide range of substituent types, it is regio- and stereospecific, and the later diversity steps are performed on solid phase. Further, the same process was applied on glucose and allose scaffolds, in the exemplified cases, and is likely adaptable to other pyranose building blocks. The methods developed in this work give access to molecules that position the three selected binding elements in various 3D orientations on a pyranose scaffold and have been applied for the production of a systematically diverse library of several hundred monosaccharide-based mimetics.
9 citations
TL;DR: Anomer preferences for galacturonic acid and its derivatives were more sensitive to solvent polarity compared to other pyranoses, and this may be linked to the electrostatic potential and reduced stabilization of the equatorial anomeric OH group due to reduced hydrogen bonding.
Abstract: Equilibrium anomeric ratios are reported for pyranoses (hemiacetals) of glucuronic and galacturonic acid and their derivatives. These are compared to related gluco- and galactopyranoses and to deoxyfluorogluco- and deoxyfluorogalactopyranoses. An association between axial anomer stability and the sum of 1H NMR downfield chemical shifts for protons H-3 and H-5 was observed in D2O with gluco- and galactopyranoses as reference compounds. When compared to 2-hydroxytetrahydropyran in water, introduction of three OAc substituents and one carboxylic acid substituent leads to an increase in stability of the axial anomer by 0.89–1.05 kcal/mol. This is interpreted as the electron-withdrawing substituents causing a reduction in the steric (gauche) interaction and an increase in favourable Coulombic interaction between CH groups of the pyranose and the anomeric group through substituent deshielding effects. Anomer preferences for galacturonic acid and its derivatives were more sensitive to solvent polarity compared t...
9 citations
Patent•
18 Jul 2007
TL;DR: A polarizing plate protection film of a cellulose ester, which exhibits high retardation stability even when left in a high-temperature, high-humidity environment for a long time is described in this paper.
Abstract: Disclosed is a polarizing plate protection film of a cellulose ester, which exhibits high retardation stability even when left in a high-temperature, high-humidity environment for a long time Also disclosed are a polarizing plate having excellent view angle stability by using such a protection film, and a liquid crystal display The polarizing plate protection film is characterized by containing a cellulose ester and a compound obtained by esterifying a part or all of OH groups in a compound (A) having one furanose structure or pyranose structure, or a compound (B) wherein not less than 2 but not more than 12 of at least one of furanose structures and pyranose structures are bonded together The polarizing plate protection film is further characterized in that the in-plate retardation Ro is not less than 0 nm but not more tha 10nm, and the thickness-direction retardation Rt is not less than -30 nm but not more than +20 nm
9 citations
TL;DR: The [Pd(II){(R,R)-chxn}(OH)(2)] reagent is introduced as a metal probe for the detection of the bidentate chelating sites of a glycose using one- and two-dimensional NMR techniques.
9 citations